| Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction KA Fitzgerald, EM Palsson-McDermott, AG Bowie, CA Jefferies, ... Nature 413 (6851), 78-83, 2001 | 1686 | 2001 |
| Targeted liposomal drug delivery to monocytes and macrophages C Kelly, C Jefferies, SA Cryan Journal of drug delivery 2011, 2011 | 471 | 2011 |
| Targeted liposomal drug delivery to monocytes and macrophages C Kelly, C Jefferies, SA Cryan Journal of Drug Delivery 2011, 2010 | 471 | 2010 |
| Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor κB activation by Toll-like receptor 4 CA Jefferies, S Doyle, C Brunner, A Dunne, E Brint, C Wietek, E Walch, ... Journal of Biological Chemistry 278 (28), 26258-26264, 2003 | 398 | 2003 |
| The E3 ubiquitin ligase Ro52 negatively regulates IFN-β production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3 R Higgs, JN Gabhann, NB Larbi, EP Breen, KA Fitzgerald, CA Jefferies The Journal of Immunology 181 (3), 1780-1786, 2008 | 341 | 2008 |
| Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23–Th17 pathway A Espinosa, V Dardalhon, S Brauner, A Ambrosi, R Higgs, FJ Quintana, ... Journal of experimental medicine 206 (8), 1661-1671, 2009 | 339 | 2009 |
| Regulating IRFs in IFN driven disease CA Jefferies Frontiers in immunology 10, 441432, 2019 | 319 | 2019 |
| MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction P Gray, A Dunne, C Brikos, CA Jefferies, SL Doyle, LAJ O'Neill Journal of Biological Chemistry 281 (15), 10489-10495, 2006 | 270 | 2006 |
| Ursodeoxycholic acid and lithocholic acid exert anti-inflammatory actions in the colon JBJ Ward, NK Lajczak, OB Kelly, AM O’Dwyer, AK Giddam, J Ní Gabhann, ... American Journal of Physiology-Gastrointestinal and Liver Physiology 312 (6 …, 2017 | 212 | 2017 |
| C9orf72 in myeloid cells suppresses STING-induced inflammation ME McCauley, JG O’Rourke, A Yáñez, JL Markman, R Ho, X Wang, ... Nature 585 (7823), 96-101, 2020 | 191 | 2020 |
| Bruton's tyrosine kinase is involved in p65-mediated transactivation and phosphorylation of p65 on serine 536 during NFκB activation by lipopolysaccharide SL Doyle, CA Jefferies, LA O'Neill Journal of Biological Chemistry 280 (25), 23496-23501, 2005 | 171 | 2005 |
| Self protection from anti-viral responses–Ro52 promotes degradation of the transcription factor IRF7 downstream of the viral Toll-Like receptors R Higgs, E Lazzari, C Wynne, J Ní Gabhann, A Espinosa, ... PloS one 5 (7), e11776, 2010 | 161 | 2010 |
| Interferon regulatory factor-3-mediated activation of the interferon-sensitive response element by Toll-like receptor (TLR) 4 but not TLR3 requires the p65 subunit of NF-κ C Wietek, SM Miggin, CA Jefferies, LAJ O'Neill Journal of Biological Chemistry 278 (51), 50923-50931, 2003 | 159 | 2003 |
| Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase SL Doyle, CA Jefferies, C Feighery, LAJ O'Neill Journal of Biological Chemistry 282 (51), 36953-36960, 2007 | 152 | 2007 |
| NF-κB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1 SM Miggin, E Pålsson-McDermott, A Dunne, C Jefferies, E Pinteaux, ... Proceedings of the National Academy of Sciences 104 (9), 3372-3377, 2007 | 146 | 2007 |
| Mal and MyD88: adapter proteins involved in signal transduction by Toll-like receptors LAJ O'Neill, A Dunne, M Edjeback, P Gray, C Jefferies, C Wietek Journal of endotoxin research 9 (1), 55-59, 2003 | 137 | 2003 |
| Btk regulates macrophage polarization in response to lipopolysaccharide J Ní Gabhann, E Hams, S Smith, C Wynne, JC Byrne, K Brennan, ... PloS one 9 (1), e85834, 2014 | 130 | 2014 |
| RETRACTED: Suppressors of cytokine signaling 2 and 3 diametrically control macrophage polarization S Spence, A Fitzsimons, CR Boyd, J Kessler, D Fitzgerald, J Elliott, ... Immunity 38 (1), 66-78, 2013 | 124 | 2013 |
| Antiviral TRIMs: friend or foe in autoimmune and autoinflammatory disease? C Jefferies, C Wynne, R Higgs Nature Reviews Immunology 11 (9), 617-625, 2011 | 112 | 2011 |
| Transactivation by the p65 subunit of NF-κB in response to interleukin-1 (IL-1) involves MyD88, IL-1 receptor-associated kinase 1, TRAF-6, and Rac1 C Jefferies, A Bowie, G Brady, EL Cooke, X Li, LAJ O'Neill Molecular and cellular biology 21 (14), 4544-4552, 2001 | 111 | 2001 |
Katherine FitzgeraldProfessor of Medicine, University of Massachusetts Medical SchoolVerified email at umassmed.edu
