| Apolipoprotein E4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer disease. J Poirier, MC Delisle, R Quirion, I Aubert, M Farlow, D Lahiri, S Hui, ... Proceedings of the National Academy of Sciences 92 (26), 12260-12264, 1995 | 787 | 1995 |
| Blood–brain barrier opening in Alzheimer’s disease using MR-guided focused ultrasound N Lipsman, Y Meng, AJ Bethune, Y Huang, B Lam, M Masellis, ... Nature communications 9 (1), 2336, 2018 | 766 | 2018 |
| Antibodies targeted to the brain with image-guided focused ultrasound reduces amyloid-β plaque load in the TgCRND8 mouse model of Alzheimer's disease JF Jordão, CA Ayala-Grosso, K Markham, Y Huang, R Chopra, ... PloS one 5 (5), e10549, 2010 | 419 | 2010 |
| Comparative alterations of nicotinic and muscarinic binding sites in Alzheimer's and Parkinson's diseases I Aubert, DM Araujo, D Cecyre, Y Robitaille, S Gauthier, R Quirion Journal of neurochemistry 58 (2), 529-541, 1992 | 412 | 1992 |
| First-in-human trial of blood–brain barrier opening in amyotrophic lateral sclerosis using MR-guided focused ultrasound A Abrahao, Y Meng, M Llinas, Y Huang, C Hamani, T Mainprize, I Aubert, ... Nature communications 10 (1), 4373, 2019 | 404 | 2019 |
| Amyloid-β plaque reduction, endogenous antibody delivery and glial activation by brain-targeted, transcranial focused ultrasound JF Jordão, E Thévenot, K Markham-Coultes, T Scarcelli, YQ Weng, ... Experimental neurology 248, 16-29, 2013 | 337 | 2013 |
| Targeted delivery of neural stem cells to the brain using MRI-guided focused ultrasound to disrupt the blood-brain barrier A Burgess, CA Ayala-Grosso, M Ganguly, JF Jordão, I Aubert, K Hynynen PloS one 6 (11), e27877, 2011 | 301 | 2011 |
| Alzheimer disease in a mouse model: MR imaging–guided focused ultrasound targeted to the hippocampus opens the blood-brain barrier and improves pathologic abnormalities and … A Burgess, S Dubey, S Yeung, O Hough, N Eterman, I Aubert, K Hynynen Radiology 273 (3), 736-745, 2014 | 288 | 2014 |
| Facilitation of acetylcholine release and cognitive performance by an M (2)-muscarinic receptor antagonist in aged memory-impaired R Quirion, A Wilson, W Rowe, I Aubert, J Richard, H Doods, A Parent, ... Journal of Neuroscience 15 (2), 1455-1462, 1995 | 256 | 1995 |
| The neuroprotective effects of exercise: maintaining a healthy brain throughout aging LM Vecchio, Y Meng, K Xhima, N Lipsman, C Hamani, I Aubert Brain plasticity 4 (1), 17-52, 2018 | 229 | 2018 |
| Regeneration in the adult mammalian CNS: guided by development I Aubert, JL Ridet, FH Gage Current opinion in neurobiology 5 (5), 625-635, 1995 | 189 | 1995 |
| Targeted delivery of self-complementary adeno-associated virus serotype 9 to the brain, using magnetic resonance imaging-guided focused ultrasound E Thévenot, JF Jordão, MA O'Reilly, K Markham, YQ Weng, KD Foust, ... Human gene therapy 23 (11), 1144-1155, 2012 | 183 | 2012 |
| Muscarinic receptor subtypes in human neurodegenerative disorders: focus on Alzheimer's disease. R Quirion, I Aubert, PA Lapchak, RP Schaum, S Teolis, S Gauthier, ... Trends in Pharmacological Sciences, 80-84, 1989 | 167 | 1989 |
| Stimulation of hippocampal neurogenesis by transcranial focused ultrasound and microbubbles in adult mice T Scarcelli, JF Jordão, MA O'reilly, N Ellens, K Hynynen, I Aubert Brain stimulation 7 (2), 304-307, 2014 | 154 | 2014 |
| Noninvasive and targeted drug delivery to the brain using focused ultrasound A Burgess, K Hynynen ACS chemical neuroscience 4 (4), 519-526, 2013 | 145 | 2013 |
| p75NTR-dependent, myelin-mediated axonal degeneration regulates neural connectivity in the adult brain KJ Park, CA Grosso, I Aubert, DR Kaplan, FD Miller Nature neuroscience 13 (5), 559-566, 2010 | 142 | 2010 |
| Comparative ontogenic profile of cholinergic markers, including nicotinic and muscarinic receptors, in the rat brain I Aubert, D Cécyre, S Gauthier, R Quirion Journal of Comparative Neurology 369 (1), 31-55, 1996 | 134 | 1996 |
| Gene delivery to the spinal cord using MRI-guided focused ultrasound D Weber-Adrian, E Thévenot, MA O'Reilly, W Oakden, MK Akens, ... Gene therapy 22 (7), 568-577, 2015 | 109 | 2015 |
| Hippocampal GABAergic neurons are susceptible to amyloid-β toxicity in vitro and are decreased in number in the Alzheimer's disease TgCRND8 mouse model S Krantic, N Isorce, N Mechawar, MA Davoli, E Vignault, M Albuquerque, ... Journal of Alzheimer's Disease 29 (2), 293-308, 2012 | 100 | 2012 |
| Expression of L1 and PSA during sprouting and regeneration in the adult hippocampal formation I Aubert, JL Ridet, M Schachner, G Rougon, FH Gage Journal of Comparative Neurology 399 (1), 1-19, 1998 | 100 | 1998 |
Kullervo HynynenProfessor of Medical Biophysics, University of TorontoVerified email at sri.utoronto.ca
