Sam Hay

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Nigel ScruttonProfessor of Enzymology, Manchester Institute of Biotechnology (MIB) and School of ChemistryVerified email at manchester.ac.uk
Linus JohannissenUniversity of ManchesterVerified email at manchester.ac.uk
David LeysProfessor in Structural Biology, Manchester UniversityVerified email at manchester.ac.uk
Derren HeyesManchester Institute of Biotechnology, University of ManchesterVerified email at manchester.ac.uk
Mike SutcliffeHead of School of Engineering, Arden UniversityVerified email at arden.ac.uk
Christopher R PudneyProfessor of Applied Biochemistry, University of BathVerified email at bath.ac.uk
Colin LevyUniversity of Manchester, Manchester Protein Structure FacilityVerified email at manchester.ac.uk
Alex R. JonesPrincipal Scientist, National Physical LaboratoryVerified email at npl.co.uk
Karl PayneUniversity of ManchesterVerified email at manchester.ac.uk
Nicole G. H. LeferinkResearch Fellow Future BRH, Manchester Intsitute of Biotechnology (MIB), University of ManchesterVerified email at manchester.ac.uk
Jiayun PangAssociate Professor in Computational Chemistry, University of GreenwichVerified email at gre.ac.uk
Andrew MunroProfessor of Molecular Enzymology, University of ManchesterVerified email at Manchester.ac.uk
Eriko TakanoProfessor of Synthetic Biology, Manchester Institute of Biotechnology, University of ManchesterVerified email at manchester.ac.uk
Perdita BarranProfessor Mass Spectrometry University of ManchesterVerified email at manchester.ac.uk
David ParkerShell International Exploration and ProductionVerified email at shell.com
Roy GoodacreDepartment of Biochemistry, Cell and Systems Biology, ISMIB, University of LiverpoolVerified email at liverpool.ac.uk
Drupad K TrivediCAMS Lecturer at University of Manchester; Manchester Institute of BiotechnologyVerified email at manchester.ac.uk
Nicholas J W RattraySenior Lecturer in Clinical MetabolismVerified email at strath.ac.uk
Hanno SjutsSanofiVerified email at sanofi.com
Robert PhillipsProfessor of Chemistry and of Biochemistry and Molecular BiologyVerified email at uga.edu

Sam Hay

Professor of Biophysical Chemistry, University of Manchester

Verified email at manchester.ac.uk - Homepage

biophysical chemistry


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Good vibrations in enzyme-catalysed reactions S Hay, NS Scrutton Nature chemistry 4 (3), 161-168, 2012	314	2012
Reductive dehalogenase structure suggests a mechanism for B12-dependent dehalogenation KAP Payne, CP Quezada, K Fisher, MS Dunstan, FA Collins, H Sjuts, ... Nature 517 (7535), 513-516, 2015	309	2015
New cofactor supports α, β-unsaturated acid decarboxylation via 1, 3-dipolar cycloaddition KAP Payne, MD White, K Fisher, B Khara, SS Bailey, D Parker, ... Nature 522 (7557), 497-501, 2015	237	2015
UbiX is a flavin prenyltransferase required for bacterial ubiquinone biosynthesis MD White, KAP Payne, K Fisher, SA Marshall, D Parker, NJW Rattray, ... Nature 522 (7557), 502-506, 2015	208	2015
Quantum biology: An update and perspective Y Kim, F Bertagna, EM D’souza, DJ Heyes, LO Johannissen, ET Nery, ... Quantum Reports 3 (1), 80-126, 2021	151	2021
Structural basis for enzymatic photocatalysis in chlorophyll biosynthesis S Zhang, DJ Heyes, L Feng, W Sun, LO Johannissen, H Liu, CW Levy, ... Nature 574 (7780), 722-725, 2019	127	2019
Promoting motions in enzyme catalysis probed by pressure studies of kinetic isotope effects S Hay, MJ Sutcliffe, NS Scrutton Proceedings of the National Academy of Sciences 104 (2), 507-512, 2007	121	2007
Fast protein motions are coupled to enzyme H-transfer reactions CR Pudney, A Guerriero, NJ Baxter, LO Johannissen, JP Waltho, S Hay, ... Journal of the American Chemical Society 135 (7), 2512-2517, 2013	104	2013
Carboxylesterase converts Amplex red to resorufin: Implications for mitochondrial H2O2 release assays S Miwa, A Treumann, A Bell, G Vistoli, G Nelson, S Hay, T von Zglinicki Free Radical Biology and Medicine 90, 173-183, 2016	94	2016
Direct Analysis of Donor− Acceptor Distance and Relationship to Isotope Effects and the Force Constant for Barrier Compression in Enzymatic H-Tunneling Reactions CR Pudney, LO Johannissen, MJ Sutcliffe, S Hay, NS Scrutton Journal of the American Chemical Society 132 (32), 11329-11335, 2010	94	2010
Evidence to support the hypothesis that promoting vibrations enhance the rate of an enzyme catalyzed H-tunneling reaction CR Pudney, S Hay, C Levy, J Pang, MJ Sutcliffe, D Leys, NS Scrutton Journal of the American Chemical Society 131 (47), 17072-17073, 2009	93	2009
Deep tunneling dominates the biologically important hydride transfer reaction from NADH to FMN in morphinone reductase J Pang, S Hay, NS Scrutton, MJ Sutcliffe Journal of the American Chemical Society 130 (22), 7092-7097, 2008	89	2008
α-Secondary isotope effects as probes of “tunneling-ready” configurations in enzymatic H-tunneling: Insight from environmentally coupled tunneling models CR Pudney, S Hay, MJ Sutcliffe, NS Scrutton Journal of the American Chemical Society 128 (43), 14053-14058, 2006	85	2006
Structural basis of catalysis in the bacterial monoterpene synthases linalool synthase and 1, 8-cineole synthase V Karuppiah, KE Ranaghan, NGH Leferink, LO Johannissen, ... Acs Catalysis 7 (9), 6268-6282, 2017	73	2017
Proton tunneling in aromatic amine dehydrogenase is driven by a short-range sub-picosecond promoting vibration: consistency of simulation and theory with experiment LO Johannissen, S Hay, NS Scrutton, MJ Sutcliffe The Journal of Physical Chemistry B 111 (10), 2631-2638, 2007	71	2007
Nature of the energy landscape for gated electron transfer in a dynamic redox protein S Hay, S Brenner, B Khara, AM Quinn, SEJ Rigby, NS Scrutton Journal of the American Chemical Society 132 (28), 9738-9745, 2010	70	2010
Barrier compression enhances an enzymatic hydrogen‐transfer reaction S Hay, CR Pudney, TA McGrory, J Pang, MJ Sutcliffe, NS Scrutton Angewandte Chemie International Edition 48 (8), 1452-1454, 2009	69	2009
Decoupled associative and dissociative processes in strong yet highly dynamic host–guest complexes EA Appel, F Biedermann, D Hoogland, J Del Barrio, MD Driscoll, S Hay, ... Journal of the American Chemical Society 139 (37), 12985-12993, 2017	67	2017
Mutagenesis of morphinone reductase induces multiple reactive configurations and identifies potential ambiguity in kinetic analysis of enzyme tunneling mechanisms CR Pudney, S Hay, J Pang, C Costello, D Leys, MJ Sutcliffe, NS Scrutton Journal of the American Chemical Society 129 (45), 13949-13956, 2007	66	2007
Engineering an efficient and enantioselective enzyme for the Morita–Baylis–Hillman reaction R Crawshaw, AE Crossley, L Johannissen, AJ Burke, S Hay, C Levy, ... Nature chemistry 14 (3), 313-320, 2022	64	2022

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