| Identifying drug effects via pathway alterations using an integer linear programming optimization formulation on phosphoproteomic data A Mitsos, IN Melas, P Siminelakis, AD Chairakaki, J Saez-Rodriguez, ... PLoS computational biology 5 (12), e1000591, 2009 | 160 | 2009 |
| Rheumatoid arthritis patients display B-cell dysregulation already in the naïve repertoire consistent with defects in B-cell tolerance Y Wang, KA Lloyd, I Melas, D Zhou, R Thyagarajan, J Lindqvist, ... Scientific reports 9 (1), 19995, 2019 | 66 | 2019 |
| The species translation challenge—a systems biology perspective on human and rat bronchial epithelial cells C Poussin, C Mathis, LG Alexopoulos, DE Messinis, RHJ Dulize, ... Scientific Data 1 (1), 1-14, 2014 | 52 | 2014 |
| Detecting and removing inconsistencies between experimental data and signaling network topologies using integer linear programming on interaction graphs IN Melas, R Samaga, LG Alexopoulos, S Klamt PLoS computational biology 9 (9), e1003204, 2013 | 52 | 2013 |
| Identification of drug-specific pathways based on gene expression data: application to drug induced lung injury IN Melas, T Sakellaropoulos, F Iorio, LG Alexopoulos, WY Loh, ... Integrative Biology 7 (8), 904-920, 2015 | 50 | 2015 |
| Phosphoproteomics in drug discovery MK Morris, A Chi, IN Melas, LG Alexopoulos Drug discovery today 19 (4), 425-432, 2014 | 40 | 2014 |
| Modeling of signaling pathways in chondrocytes based on phosphoproteomic and cytokine release data IN Melas, AD Chairakaki, EI Chatzopoulou, DE Messinis, T Katopodi, ... Osteoarthritis and Cartilage 22 (3), 509-518, 2014 | 40 | 2014 |
| Combined logical and data-driven models for linking signalling pathways to cellular response IN Melas, A Mitsos, DE Messinis, TS Weiss, LG Alexopoulos BMC systems biology 5, 1-12, 2011 | 34 | 2011 |
| Signaling networks in MS: a systems-based approach to developing new pharmacological therapies E Kotelnikova, M Bernardo-Faura, G Silberberg, NA Kiani, D Messinis, ... Multiple Sclerosis Journal 21 (2), 138-146, 2015 | 31 | 2015 |
| Non Linear Programming (NLP) formulation for quantitative modeling of protein signal transduction pathways A Mitsos, IN Melas, MK Morris, J Saez-Rodriguez, DA Lauffenburger, ... PLoS One 7 (11), e50085, 2012 | 21 | 2012 |
| Construction of large signaling pathways using an adaptive perturbation approach with phosphoproteomic data IN Melas, A Mitsos, DE Messinis, TS Weiss, JS Rodriguez, ... Molecular Biosystems 8 (5), 1571-1584, 2012 | 16 | 2012 |
| Translational systems pharmacology‐based predictive assessment of drug‐induced cardiomyopathy DE Messinis, IN Melas, J Hur, N Varshney, LG Alexopoulos, JPF Bai CPT: Pharmacometrics & Systems Pharmacology 7 (3), 166-174, 2018 | 14 | 2018 |
| Construction of Cell Type-Specific Logic Models of Signaling Networks Using CellNOpt MK Morris, I Melas, J Saez-Rodriguez Computational Toxicology: Volume II, 179-214, 2013 | 13 | 2013 |
| A crowd-sourcing approach for the construction of species-specific cell signaling networks E Bilal, T Sakellaropoulos, C Participants, IN Melas, DE Messinis, ... Bioinformatics 31 (4), 484-491, 2014 | 12 | 2014 |
| Advances in omics for informed pharmaceutical research and development in the era of systems medicine JPF Bai, IN Melas, J Hur, E Guo Expert opinion on drug discovery 13 (1), 1-4, 2018 | 10 | 2018 |
| Network‐based analysis of nutraceuticals in human hepatocellular carcinomas reveals mechanisms of chemopreventive action M Michailidou, IN Melas, DE Messinis, S Klamt, LG Alexopoulos, ... CPT: pharmacometrics & systems pharmacology 4 (6), 350-361, 2015 | 8 | 2015 |
| Leveraging systems biology approaches in clinical pharmacology IN Melas, K Kretsos, LG Alexopoulos Biopharmaceutics & drug disposition 34 (9), 477-488, 2013 | 8 | 2013 |
| Construction of signaling pathways and identification of drug effects on the liver cancer cell HepG2 LG Alexopoulos, IN Melas, AD Chairakaki, J Saez-Rodriguez, A Mitsos 2010 Annual International Conference of the IEEE Engineering in Medicine and …, 2010 | 8 | 2010 |
| Network reconstruction based on proteomic data and prior knowledge of protein connectivity using graph theory V Stavrakas, IN Melas, T Sakellaropoulos, LG Alexopoulos PLoS One 10 (5), e0128411, 2015 | 5 | 2015 |
| Identification of signaling pathways related to drug efficacy in hepatocellular carcinoma via integration of phosphoproteomic, genomic and clinical data IN Melas, DA Lauffenburger, LG Alexopoulos 13th IEEE International Conference on BioInformatics and BioEngineering, 1-4, 2013 | 4 | 2013 |
