David R. Kaplan
David R. Kaplan
Hospital for Sick Children
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Regulation of neuronal survival by the serine-threonine protein kinase Akt
H Dudek, SR Datta, TF Franke, MJ Birnbaum, R Yao, GM Cooper, ...
Science 275 (5300), 661-665, 1997
The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
TF Franke, SI Yang, TO Chan, K Datta, A Kazlauskas, DK Morrison, ...
Cell 81 (5), 727-736, 1995
Neurotrophin signal transduction in the nervous system
DR Kaplan, FD Miller
Current opinion in neurobiology 10 (3), 381-391, 2000
PI3K: downstream AKTion blocks apoptosis
TF Franke, DR Kaplan, LC Cantley
Cell 88 (4), 435-437, 1997
Isolation of multipotent adult stem cells from the dermis of mammalian skin
JG Toma, M Akhavan, KJL Fernandes, F Barnabé-Heider, A Sadikot, ...
Nature cell biology 3 (9), 778-784, 2001
Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3, 4-bisphosphate
TF Franke, DR Kaplan, LC Cantley, A Toker
Science 275 (5300), 665-668, 1997
The trk proto-oncogene product: a signal transducing receptor for nerve growth factor
DR Kaplan, BL Hempstead, D Martin-Zanca, MV Chao, LF Parada
Science 252 (5005), 554-558, 1991
High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor
BL Hempstead, D Martin-Zanca, DR Kaplan, LF Parada, MV Chao
Nature 350 (6320), 678-683, 1991
Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF
DR Kaplan, D Martin-Zanca, LF Parada
Nature 350 (6314), 158-160, 1991
Neurotrophin-5: a novel neurotrophic factor that activates trk and trkB
LR Berkemeier, JW Winslow, DR Kaplan, K Nikolics, DV Goeddel, ...
Neuron 7 (5), 857-866, 1991
Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation
M Whitman, DR Kaplan, B Schaffhausen, L Cantley, TM Roberts
Nature 315 (6016), 239-242, 1985
The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor
D Soppet, E Escandon, J Maragos, DS Middlemas, SW Raid, J Blair, ...
Cell 65 (5), 895-903, 1991
A dermal niche for multipotent adult skin-derived precursor cells
KJL Fernandes, IA McKenzie, P Mill, KM Smith, M Akhavan, ...
Nature cell biology 6 (11), 1082-1093, 2004
Signal transduction by the neutrophin receptors
DR Kaplan, FD Miller
Current opinion in cell biology 9 (2), 213-221, 1997
Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity
DR Kaplan, M Whitman, B Schaffhausen, DC Pallas, M White, L Cantley, ...
Cell 50 (7), 1021-1029, 1987
Trk receptors use redundant signal transduction pathways involving SHC and PLC-γ1 to mediate NGF responses
RM Stephens, DM Loeb, TD Copeland, T Pawson, LA Greene, DR Kaplan
Neuron 12 (3), 691-705, 1994
Neurotrophin signal transduction by the Trk receptor
DR Kaplan, RM Stephens
Journal of neurobiology 25 (11), 1404-1417, 1994
PDGF β-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex
DR Kaplan, DK Morrison, G Wong, F McCormick, LT Williams
Cell 61 (1), 125-133, 1990
An anti-apoptotic role for the p53 family member, p73, during developmental neuron death
CD Pozniak, S Radinovic, A Yang, F McKeon, DR Kaplan, FD Miller
Science 289 (5477), 304-306, 2000
Direct activation of the serine/threonine kinase activity of Raf-1 through tyrosine phosphorylation by the PDGF β-receptor
DK Morrison, DR Kaplan, JA Escobedo, UR Rapp, TM Roberts, ...
Cell 58 (4), 649-657, 1989
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