Lucas Hoffman
Lucas Hoffman
Professor of Pediatrics and Microbiology, University of Washington
Verified email at
Cited by
Cited by
Genetic adaptation by Pseudomonas aeruginosa to the airways of cystic fibrosis patients
EE Smith, DG Buckley, Z Wu, C Saenphimmachak, LR Hoffman, ...
Proceedings of the National Academy of Sciences 103 (22), 8487-8492, 2006
Aminoglycoside antibiotics induce bacterial biofilm formation
LR Hoffman, DA D'Argenio, MJ MacCoss, Z Zhang, RA Jones, SI Miller
Nature 436 (7054), 1171-1175, 2005
Virus-cell and cell-cell fusion
LD Hernandez, LR Hoffman, TG Wolfsberg, JM White
Annual review of cell and developmental biology 12 (1), 627-661, 1996
Failure to recover to baseline pulmonary function after cystic fibrosis pulmonary exacerbation
DB Sanders, RCL Bittner, M Rosenfeld, LR Hoffman, GJ Redding, ...
American journal of respiratory and critical care medicine 182 (5), 627-632, 2010
Selection for Staphylococcus aureus small-colony variants due to growth in the presence of Pseudomonas aeruginosa
LR Hoffman, E Déziel, DA d'Argenio, F Lépine, J Emerson, S McNamara, ...
Proceedings of the National Academy of Sciences 103 (52), 19890-19895, 2006
Growth phenotypes of Pseudomonas aeruginosa lasR mutants adapted to the airways of cystic fibrosis patients
DA D'Argenio, M Wu, LR Hoffman, HD Kulasekara, E Déziel, EE Smith, ...
Molecular microbiology 64 (2), 512-533, 2007
Restoring cystic fibrosis transmembrane conductance regulator function reduces airway bacteria and inflammation in people with cystic fibrosis and chronic lung infections
KB Hisert, SL Heltshe, C Pope, P Jorth, X Wu, RM Edwards, M Radey, ...
American journal of respiratory and critical care medicine 195 (12), 1617-1628, 2017
Pseudomonas aeruginosa lasR mutants are associated with cystic fibrosis lung disease progression
LR Hoffman, HD Kulasekara, J Emerson, LS Houston, JL Burns, ...
Journal of Cystic Fibrosis 8 (1), 66-70, 2009
Asymmetrical distribution of the second messenger c-di-GMP upon bacterial cell division
M Christen, HD Kulasekara, B Christen, BR Kulasekara, LR Hoffman, ...
Science 328 (5983), 1295-1297, 2010
LasR variant cystic fibrosis isolates reveal an adaptable quorum-sensing hierarchy in Pseudomonas aeruginosa
JB Feltner, DJ Wolter, CE Pope, MC Groleau, NE Smalley, EP Greenberg, ...
MBio 7 (5), 10.1128/mbio. 01513-16, 2016
Clinical effectiveness of elexacaftor/tezacaftor/ivacaftor in people with cystic fibrosis: a clinical trial
DP Nichols, AC Paynter, SL Heltshe, SH Donaldson, CA Frederick, ...
American journal of respiratory and critical care medicine 205 (5), 529-539, 2022
Staphylococcus aureus Small-Colony Variants Are Independently Associated With Worse Lung Disease in Children With Cystic Fibrosis
DJ Wolter, JC Emerson, S McNamara, AM Buccat, X Qin, E Cochrane, ...
Clinical Infectious Diseases 57 (3), 384-391, 2013
Lung function and microbiota diversity in cystic fibrosis
L Cuthbertson, AW Walker, AE Oliver, GB Rogers, DW Rivett, ...
Microbiome 8, 1-13, 2020
The microbiota in bronchoalveolar lavage from young children with chronic lung disease includes taxa present in both the oropharynx and nasopharynx
RL Marsh, M Kaestli, AB Chang, MJ Binks, CE Pope, LR Hoffman, ...
Microbiome 4, 1-18, 2016
Long-term cultivation-independent microbial diversity analysis demonstrates that bacterial communities infecting the adult cystic fibrosis lung show stability and resilience
FA Stressmann, GB Rogers, CJ Van Der Gast, P Marsh, LS Vermeer, ...
Thorax 67 (10), 867-873, 2012
Does bacterial density in cystic fibrosis sputum increase prior to pulmonary exacerbation?
FA Stressmann, GB Rogers, P Marsh, AK Lilley, TWV Daniels, MP Carroll, ...
Journal of Cystic Fibrosis 10 (5), 357-365, 2011
Return of FEV1 after pulmonary exacerbation in children with cystic fibrosis
DB Sanders, LR Hoffman, J Emerson, RL Gibson, M Rosenfeld, ...
Pediatric pulmonology 45 (2), 127-134, 2010
Nutrient Availability as a Mechanism for Selection of Antibiotic Tolerant Pseudomonas aeruginosa within the CF Airway
LR Hoffman, AR Richardson, LS Houston, HD Kulasekara, ...
PLoS pathogens 6 (1), e1000712, 2010
Structure-based identification of an inducer of the low-pH conformational change in the influenza virus hemagglutinin: irreversible inhibition of infectivity
LR Hoffman, ID Kuntz, JM White
Journal of Virology 71 (11), 8808-8820, 1997
Pseudomonas aeruginosa in vitro phenotypes distinguish cystic fibrosis infection stages and outcomes
N Mayer-Hamblett, M Rosenfeld, RL Gibson, BW Ramsey, HD Kulasekara, ...
American journal of respiratory and critical care medicine 190 (3), 289-297, 2014
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