Isolation of llama antibody fragments for prevention of dandruff by phage display in shampoo E Dolk, M van der Vaart, D Lutje Hulsik, G Vriend, H de Haard, S Spinelli, ... Applied and environmental microbiology 71 (1), 442-450, 2005 | 175 | 2005 |
Charged multivesicular body protein 2B (CHMP2B) of the endosomal sorting complex required for transport-III (ESCRT-III) polymerizes into helical structures deforming the plasma … G Bodon, R Chassefeyre, K Pernet-Gallay, N Martinelli, G Effantin, ... Journal of Biological Chemistry 286 (46), 40276-40286, 2011 | 115 | 2011 |
Crystal structure and size-dependent neutralization properties of HK20, a human monoclonal antibody binding to the highly conserved heptad repeat 1 of gp41 C Sabin, D Corti, V Buzon, MS Seaman, D Lutje Hulsik, A Hinz, ... PLoS pathogens 6 (11), e1001195, 2010 | 93 | 2010 |
A gp41 MPER-specific llama VHH requires a hydrophobic CDR3 for neutralization but not for antigen recognition D Lutje Hulsik, Y Liu, NM Strokappe, S Battella, M El Khattabi, LE McCoy, ... PLoS pathogens 9 (3), e1003202, 2013 | 85 | 2013 |
Llama antibody fragments recognizing various epitopes of the CD4bs neutralize a broad range of HIV-1 subtypes A, B and C N Strokappe, A Szynol, M Aasa-Chapman, A Gorlani, A Forsman Quigley, ... PloS one 7 (3), e33298, 2012 | 74 | 2012 |
Heavier-than-air flying machines are impossible L Oliveira, T Hulsen, DL Hulsik, ACM Paiva, G Vriend FEBS letters 564 (3), 269-273, 2004 | 66 | 2004 |
Functional characterization of the selective pan-allele anti-SIRPα antibody ADU-1805 that blocks the SIRPα–CD47 innate immune checkpoint E Voets, M Paradé, D Lutje Hulsik, S Spijkers, W Janssen, J Rens, ... Journal for immunotherapy of cancer 7, 1-15, 2019 | 58 | 2019 |
Structural basis for ESCRT-III CHMP3 recruitment of AMSH J Solomons, C Sabin, E Poudevigne, Y Usami, DL Hulsik, P Macheboeuf, ... Structure 19 (8), 1149-1159, 2011 | 58 | 2011 |
A fusion intermediate gp41 immunogen elicits neutralizing antibodies to HIV-1 RPJ Lai, M Hock, J Radzimanowski, P Tonks, DL Hulsik, G Effantin, ... Journal of Biological Chemistry 289 (43), 29912-29926, 2014 | 48 | 2014 |
Crystal Structure of the Neutralizing Llama VHH D7 and Its Mode of HIV-1 gp120 Interaction A Hinz, D Lutje Hulsik, A Forsman, WWL Koh, H Belrhali, A Gorlani, ... PloS one 5 (5), e10482, 2010 | 43 | 2010 |
Characterization of a trimeric MPER containing HIV-1 gp41 antigen A Hinz, G Schoehn, H Quendler, DL Hulsik, G Stiegler, H Katinger, ... Virology 390 (2), 221-227, 2009 | 43 | 2009 |
Antibody engineering reveals the important role of J segments in the production efficiency of llama single-domain antibodies in Saccharomyces cerevisiae A Gorlani, D Lutje Hulsik, H Adams, G Vriend, P Hermans, T Verrips Protein Engineering, Design & Selection 25 (1), 39-46, 2012 | 41 | 2012 |
Calpain 3 is a rapid-action, unidirectional proteolytic switch central to muscle remodeling A de Morrée, D Lutje Hulsik, A Impagliazzo, HH van Haagen, P de Galan, ... PLoS One 5 (8), e11940, 2010 | 30 | 2010 |
Altered APRIL binding antibodies H Van Eenennaam, A Van Elsas, DL Hulsik, JP Medema US Patent 9,969,808, 2018 | 15 | 2018 |
A novel efficient bispecific antibody format, combining a conventional antigen-binding fragment with a single domain antibody, avoids potential heavy-light chain mis-pairing S Huang, A Segués, DL Hulsik, DM Zaiss, AJAM Sijts, ... Journal of immunological methods 483, 112811, 2020 | 11 | 2020 |
Anti-SIRPα antibodies H Van Eenennaam, A Van Elsas, E Voets, V Paul, DL Hulsik US Patent 10,851,164, 2020 | 8 | 2020 |
Anti-PD-1 antibodies H Van Eenennaam, A Van Elsas, J Kreijtz, DL Hulsik, CRR Dos Reis US Patent 10,494,436, 2019 | 8 | 2019 |
Method of treating IgA nephropathy by administering humanized APRIL-binding antibodies H Van Eenennaam, A Van Elsas, DL Hulsik, JP Medema US Patent 10,377,830, 2019 | 8 | 2019 |
Preclinical characterization and clinical translation of pharmacodynamic markers for MK-5890: a human CD27 activating antibody for cancer immunotherapy L Guelen, TO Fischmann, J Wong, S Mauze, M Guadagnoli, N Bąbała, ... Journal for Immunotherapy of Cancer 10 (9), 2022 | 7 | 2022 |
Improving properties of llama heavy chain antibodies using in silico analysis D Lutje Hulsik Utrecht University, 2009 | 4 | 2009 |