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HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells
P Cherepanov, G Maertens, P Proost, B Devreese, J Van Beeumen, ...
Journal of Biological Chemistry 278 (1), 372-381, 2003
LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells
G Maertens, P Cherepanov, W Pluymers, K Busschots, E De Clercq, ...
Journal of Biological Chemistry 278 (35), 33528-33539, 2003
Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication
F Christ, A Voet, A Marchand, S Nicolet, BA Desimmie, D Marchand, ...
Nature chemical biology 6 (6), 442-448, 2010
Rapid, simple, and versatile manufacturing of recombinant adeno-associated viral vectors at scale
M Lock, M Alvira, LH Vandenberghe, A Samanta, J Toelen, Z Debyser, ...
Human gene therapy 21 (10), 1259-1271, 2010
Highly potent and selective inhibition of human immunodeficiency virus by the bicyclam derivative JM3100
E De Clercq, N Yamamoto, R Pauwels, J Balzarini, M Witvrouw, ...
Antimicrobial agents and chemotherapy 38 (4), 668-674, 1994
Comparative analysis of adeno-associated viral vector serotypes 1, 2, 5, 7, and 8 in mouse brain
JM Taymans, LH Vandenberghe, CVD Haute, I Thiry, CM Deroose, ...
Human gene therapy 18 (3), 195-206, 2007
Potent and selective inhibition of human immunodeficiency virus (HIV)-1 and HIV-2 replication by a class of bicyclams interacting with a viral uncoating event.
E De Clercq, N Yamamoto, R Pauwels, M Baba, D Schols, H Nakashima, ...
Proceedings of the National Academy of Sciences 89 (12), 5286-5290, 1992
Integrase Mutants Defective for Interaction with LEDGF/p75 Are Impairedin Chromosome Tethering and HIV-1Replication
S Emiliani, A Mousnier, K Busschots, M Maroun, B Van Maele, D Tempé, ...
Journal of Biological Chemistry 280 (27), 25517-25523, 2005
Transportin-SR2 imports HIV into the nucleus
F Christ, W Thys, J De Rijck, R Gijsbers, A Albanese, D Arosio, S Emiliani, ...
Current Biology 18 (16), 1192-1202, 2008
Transient and stable knockdown of the integrase cofactor LEDGF/p75 reveals its role in the replication cycle of human immunodeficiency virus
L Vandekerckhove, F Christ, B Van Maele, J De Rijck, R Gijsbers, ...
Journal of virology 80 (4), 1886-1896, 2006
The interaction of LEDGF/p75 with integrase is lentivirus-specific and promotes DNA binding
K Busschots, J Vercammen, S Emiliani, R Benarous, Y Engelborghs, ...
Journal of Biological Chemistry 280 (18), 17841-17847, 2005
Cellular co-factors of HIV-1 integration
B Van Maele, K Busschots, L Vandekerckhove, F Christ, Z Debyser
Trends in biochemical sciences 31 (2), 98-105, 2006
Potent and highly selective human immunodeficiency virus type 1 (HIV-1) inhibition by a series of alpha-anilinophenylacetamide derivatives targeted at HIV-1 reverse transcriptase.
R Pauwels, K Andries, Z Debyser, P Van Daele, D Schols, P Stoffels, ...
Proceedings of the National Academy of Sciences 90 (5), 1711-1715, 1993
An antiviral target on reverse transcriptase of human immunodeficiency virus type 1 revealed by tetrahydroimidazo-[4, 5, 1-jk][1, 4] benzodiazepin-2 (1H)-one and-thione …
Z Debyser, R Pauwels, K Andries, J Desmyter, M Kukla, PA Janssen, ...
Proceedings of the National Academy of Sciences 88 (4), 1451-1455, 1991
Comparison of lentiviral vector titration methods
M Geraerts, S Willems, V Baekelandt, Z Debyser, R Gijsbers
BMC biotechnology 6, 1-10, 2006
Upscaling of lentiviral vector production by tangential flow filtration
M Geraerts, M Michiels, V Baekelandt, Z Debyser, R Gijsbers
The Journal of Gene Medicine: A cross‐disciplinary journal for research on …, 2005
Chicoric acid analogues as HIV-1 integrase inhibitors
Z Lin, N Neamati, H Zhao, Y Kiryu, JA Turpin, C Aberham, K Strebel, ...
Journal of medicinal chemistry 42 (8), 1401-1414, 1999
Depletion of PINK1 affects mitochondrial metabolism, calcium homeostasis and energy maintenance
B Heeman, C Van den Haute, SA Aelvoet, F Valsecchi, RJ Rodenburg, ...
Journal of cell science 124 (7), 1115-1125, 2011
Polyanionic (ie, polysulfonate) dendrimers can inhibit the replication of human immunodeficiency virus by interfering with both virus adsorption and later steps (reverse …
M Witvrouw, V Fikkert, W Pluymers, B Matthews, K Mardel, D Schols, ...
Molecular pharmacology 58 (5), 1100-1108, 2000
Small-molecule inhibitors of the LEDGF/p75 binding site of integrase block HIV replication and modulate integrase multimerization
F Christ, S Shaw, J Demeulemeester, BA Desimmie, A Marchand, S Butler, ...
Antimicrobial agents and chemotherapy 56 (8), 4365-4374, 2012
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