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Christopher Vakoc
Christopher Vakoc
Verified email at cshl.edu - Homepage
Title
Cited by
Cited by
Year
BET bromodomain inhibition as a therapeutic strategy to target c-Myc
JE Delmore, GC Issa, ME Lemieux, PB Rahl, J Shi, HM Jacobs, E Kastritis, ...
Cell 146 (6), 904-917, 2011
32282011
Selective inhibition of tumor oncogenes by disruption of super-enhancers
J Lovén, HA Hoke, CY Lin, A Lau, DA Orlando, CR Vakoc, JE Bradner, ...
Cell 153 (2), 320-334, 2013
29882013
RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
J Zuber, J Shi, E Wang, AR Rappaport, H Herrmann, EA Sison, D Magoon, ...
Nature 478 (7370), 524-528, 2011
21752011
Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data
CM Rudin, JT Poirier, LA Byers, C Dive, A Dowlati, J George, JV Heymach, ...
Nature Reviews Cancer 19 (5), 289-297, 2019
10382019
Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control
I Barbieri, K Tzelepis, L Pandolfini, J Shi, G Millán-Zambrano, SC Robson, ...
Nature 552 (7683), 126-131, 2017
10022017
Organoid profiling identifies common responders to chemotherapy in pancreatic cancer
H Tiriac, P Belleau, DD Engle, D Plenker, A Deschęnes, TDD Somerville, ...
Cancer discovery 8 (9), 1112-1129, 2018
9452018
Histone H3 lysine 9 methylation and HP1γ are associated with transcription elongation through mammalian chromatin
CR Vakoc, SA Mandat, BA Olenchock, GA Blobel
Molecular cell 19 (3), 381-391, 2005
9312005
The mechanisms behind the therapeutic activity of BET bromodomain inhibition
J Shi, CR Vakoc
Molecular cell 54 (5), 728-736, 2014
9222014
Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domains
J Shi, E Wang, JP Milazzo, Z Wang, JB Kinney, CR Vakoc
Nature biotechnology 33 (6), 661-667, 2015
8182015
Proximity among distant regulatory elements at the β-globin locus requires GATA-1 and FOG-1
CR Vakoc, DL Letting, N Gheldof, T Sawado, MA Bender, M Groudine, ...
Molecular cell 17 (3), 453-462, 2005
6362005
DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells
DJ Steger, MI Lefterova, L Ying, AJ Stonestrom, M Schupp, D Zhuo, ...
Molecular and cellular biology 28 (8), 2825-2839, 2008
5912008
Transcriptional plasticity promotes primary and acquired resistance to BET inhibition
P Rathert, M Roth, T Neumann, F Muerdter, JS Roe, M Muhar, S Deswal, ...
Nature 525 (7570), 543-547, 2015
5212015
Global regulation of erythroid gene expression by transcription factor GATA-1
JJ Welch, JA Watts, CR Vakoc, Y Yao, H Wang, RC Hardison, GA Blobel, ...
Blood 104 (10), 3136-3147, 2004
5102004
Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation
J Shi, WA Whyte, CJ Zepeda-Mendoza, JP Milazzo, C Shen, JS Roe, ...
Genes & development 27 (24), 2648-2662, 2013
5022013
Profile of histone lysine methylation across transcribed mammalian chromatin
CR Vakoc, MM Sachdeva, H Wang, GA Blobel
Molecular and cellular biology, 2006
4742006
Enhancer reprogramming promotes pancreatic cancer metastasis
JS Roe, CI Hwang, TDD Somerville, JP Milazzo, EJ Lee, B Da Silva, ...
Cell 170 (5), 875-888. e20, 2017
4362017
BRD4 connects enhancer remodeling to senescence immune surveillance
N Tasdemir, A Banito, JS Roe, D Alonso-Curbelo, M Camiolo, ...
Cancer discovery 6 (6), 612-629, 2016
371*2016
POU2F3 is a master regulator of a tuft cell-like variant of small cell lung cancer
YH Huang, O Klingbeil, XY He, XS Wu, G Arun, B Lu, TDD Somerville, ...
Genes & development 32 (13-14), 915-928, 2018
3702018
BET bromodomain inhibition suppresses the function of hematopoietic transcription factors in acute myeloid leukemia
JS Roe, F Mercan, K Rivera, DJ Pappin, CR Vakoc
Molecular cell 58 (6), 1028-1039, 2015
3592015
The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability
B King, T Trimarchi, L Reavie, L Xu, J Mullenders, P Ntziachristos, ...
Cell 153 (7), 1552-1566, 2013
3582013
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