David Brough
David Brough
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Understanding the mechanism of IL-1β secretion
G Lopez-Castejon, D Brough
Cytokine & growth factor reviews 22 (4), 189-195, 2011
The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response
A Baroja-Mazo, F Martín-Sánchez, AI Gomez, CM Martínez, ...
Nature immunology 15 (8), 738-748, 2014
Consensus guidelines for the detection of immunogenic cell death
O Kepp, L Senovilla, I Vitale, E Vacchelli, S Adjemian, P Agostinis, ...
Oncoimmunology 3 (9), e955691, 2014
Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer’s disease in rodent models
MJD Daniels, J Rivers-Auty, T Schilling, NG Spencer, W Watremez, ...
Nature communications 7 (1), 12504, 2016
Caspase-1-dependent processing of pro-interleukin-1β is cytosolic and precedes cell death
D Brough, NJ Rothwell
Journal of cell science 120 (5), 772-781, 2007
Molecular and translational classifications of DAMPs in immunogenic cell death
AD Garg, L Galluzzi, L Apetoh, T Baert, RB Birge, JM Bravo-San Pedro, ...
Frontiers in immunology 6, 588, 2015
Caspase-1: is IL-1 just the tip of the ICEberg?
A Denes, G Lopez-Castejon, D Brough
Cell death & disease 3 (7), e338-e338, 2012
Brain injury induces specific changes in the caecal microbiota of mice via altered autonomic activity and mucoprotein production
A Houlden, M Goldrick, D Brough, ES Vizi, N Lénárt, B Martinecz, ...
Brain, behavior, and immunity 57, 10-20, 2016
Inflammasome-dependent IL-1β release depends upon membrane permeabilisation
F Martín-Sánchez, C Diamond, M Zeitler, AI Gomez, A Baroja-Mazo, ...
Cell Death & Differentiation 23 (7), 1219-1231, 2016
Priming of macrophages with lipopolysaccharide potentiates P2X7-mediated cell death via a caspase-1-dependent mechanism, independently of cytokine production
RA Le Feuvre, D Brough, Y Iwakura, K Takeda, NJ Rothwell
Journal of Biological Chemistry 277 (5), 3210-3218, 2002
Ca2+ stores and Ca2+ entry differentially contribute to the release of IL-1β and IL-1α from murine macrophages
D Brough, RA Le Feuvre, RD Wheeler, N Solovyova, S Hilfiker, ...
The Journal of Immunology 170 (6), 3029-3036, 2003
AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3
A Denes, G Coutts, N Lénárt, SM Cruickshank, P Pelegrin, J Skinner, ...
Proceedings of the National Academy of Sciences 112 (13), 4050-4055, 2015
Deubiquitinases regulate the activity of caspase-1 and interleukin-1β secretion via assembly of the inflammasome
G Lopez-Castejon, NM Luheshi, V Compan, S High, RC Whitehead, ...
Journal of Biological Chemistry 288 (4), 2721-2733, 2013
Extracellular ATP and P2X7 receptors in neurodegeneration
R Le Feuvre, D Brough, N Rothwell
European journal of pharmacology 447 (2-3), 261-269, 2002
NLRP3-inflammasome activating DAMPs stimulate an inflammatory response in glia in the absence of priming which contributes to brain inflammation after injury
CD Savage, G Lopez-Castejon, A Denes, D Brough
Frontiers in immunology 3, 288, 2012
Interleukin-1α expression precedes IL-1β after ischemic brain injury and is localised to areas of focal neuronal loss and penumbral tissues
NM Luheshi, KJ Kovács, G Lopez-Castejon, D Brough, A Denes
Journal of neuroinflammation 8, 1-5, 2011
Microglia and macrophages differentially modulate cell death after brain injury caused by oxygen‐glucose deprivation in organotypic brain slices
S Girard, D Brough, G Lopez‐Castejon, J Giles, NJ Rothwell, SM Allan
Glia 61 (5), 813-824, 2013
Purinergic (P2X7) receptor activation of microglia induces cell death via an interleukin-1-independent mechanism
D Brough, RA Le Feuvre, Y Iwakura, NJ Rothwell
Molecular and Cellular Neuroscience 19 (2), 272-280, 2002
Inflammasomes link vascular disease with neuroinflammation and brain disorders
N Lénárt, D Brough, Á Dénes
Journal of Cerebral Blood Flow & Metabolism 36 (10), 1668-1685, 2016
Role of P2X7 Receptors in Ischemic and Excitotoxic Brain Injury In Vivo
RA Le Feuvre, D Brough, O Touzani, NJ Rothwell
Journal of Cerebral Blood Flow & Metabolism 23 (3), 381-384, 2003
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