Role of AMP-activated protein kinase in mechanism of metformin action G Zhou, R Myers, Y Li, Y Chen, X Shen, J Fenyk-Melody, M Wu, J Ventre, ... The Journal of clinical investigation 108 (8), 1167-1174, 2001 | 6786 | 2001 |
Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase SJ Darkin-Rattray, AM Gurnett, RW Myers, PM Dulski, TM Crumley, ... Proceedings of the National Academy of Sciences 93 (23), 13143-13147, 1996 | 719 | 1996 |
Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy RW Myers, HP Guan, J Ehrhart, A Petrov, S Prahalada, E Tozzo, X Yang, ... Science 357 (6350), 507-511, 2017 | 264 | 2017 |
The synthesis of 4-methylumbelliferyl α-ketoside of N-acetylneuraminic acid and its use in a fluorometric assay for neuraminidase RW Myers, RT Lee, YC Lee, GH Thomas, LW Reynolds, Y Uchida Analytical biochemistry 101 (1), 166-174, 1980 | 197 | 1980 |
Mechanism-Based Inhibition of human steroid 5α-reductase by finasteride: Enzyme-catalyzed formation of NADP− dihydrofinasteride, a potent bisubstrate analog inhibitor HG Bull, M Garcia-Calvo, S Andersson, WF Baginsky, HK Chan, ... Journal of the American Chemical Society 118 (10), 2359-2365, 1996 | 181 | 1996 |
Antidiabetic and antisteatotic effects of the selective fatty acid synthase (FAS) inhibitor platensimycin in mouse models of diabetes M Wu, SB Singh, J Wang, CC Chung, G Salituro, BV Karanam, SH Lee, ... Proceedings of the National Academy of Sciences 108 (13), 5378-5383, 2011 | 177 | 2011 |
Glucose-lowering in a db/db mouse model by dihydropyridine diacid glycogen phosphorylase inhibitors AK Ogawa, CA Willoughby, R Bergeron, KP Ellsworth, WM Geissler, ... Bioorganic & medicinal chemistry letters 13 (20), 3405-3408, 2003 | 107 | 2003 |
Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure–activity relationships of apicidin. Part 1 SL Colletti, RW Myers, SJ Darkin-Rattray, AM Gurnett, PM Dulski, ... Bioorganic & medicinal chemistry letters 11 (2), 107-111, 2001 | 105 | 2001 |
Purification and characterization of an enzyme involved in oxidative carbon-carbon bond cleavage reactions in the methionine salvage pathway of Klebsiella pneumoniae. RW Myers, JW Wray, S Fish, RH Abeles Journal of Biological Chemistry 268 (33), 24785-24791, 1993 | 91 | 1993 |
Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure–activity relationships of apicidin. Part 2 SL Colletti, RW Myers, SJ Darkin-Rattray, AM Gurnett, PM Dulski, ... Bioorganic & medicinal chemistry letters 11 (2), 113-117, 2001 | 88 | 2001 |
N-Substituted (β-D-galactopyranosylmethyl) amines, and C-β-D-galactopyranosylformamides, and related compounds JN BeMiller, MP Yadav, VN Kalabokis, RW Myers Carbohydrate Research 200, 111-126, 1990 | 81 | 1990 |
Synthesis of apicidin-derived quinolone derivatives: parasite-selective histone deacetylase inhibitors and antiproliferative agents PT Meinke, SL Colletti, G Doss, RW Myers, AM Gurnett, PM Dulski, ... Journal of medicinal chemistry 43 (25), 4919-4922, 2000 | 77 | 2000 |
Synthesis and characterization of some anomeric pairs of per-O-acetylated aldohexopyranosyl cyanides (per-O-acetylated 2, 6-anhydroheptononitriles). On the reaction of per-O … RW Myers, YC Lee Carbohydrate research 132 (1), 61-82, 1984 | 77 | 1984 |
Development of a scintillation proximity assay for histone deacetylase using a biotinylated peptide derived from histone-H4 B Nare, JJ Allocco, R Kuningas, S Galuska, RW Myers, MA Bednarek, ... Analytical biochemistry 267 (2), 390-396, 1999 | 73 | 1999 |
Histone deacetylase as target for antiprotozoal agents PM Dulski, RW Myers, AM Gurnett, SJ Rattray, DM Schmatz US Patent 6,068,987, 2000 | 68 | 2000 |
Further studies on the binding characteristics of rabbit liver galactose/N-acetylgalactosamine-specific lectin RT Lee, RW Myers, YC Lee Biochemistry 21 (24), 6292-6298, 1982 | 60 | 1982 |
Novel 3, 4-dihydroquinolin-2 (1H)-one inhibitors of human glycogen phosphorylase a KG Rosauer, AK Ogawa, CA Willoughby, KP Ellsworth, WM Geissler, ... Bioorganic & medicinal chemistry letters 13 (24), 4385-4388, 2003 | 59 | 2003 |
Synthesis of diazomethyl β-D-galactopyranosyl and β-D-glucopyranosyl ketones. Potential affinity-labeling reagents for carbohydrate-binding proteins RW Myers, YC Lee Carbohydrate research 152, 143-158, 1986 | 57 | 1986 |
A new class of glycogen phosphorylase inhibitors Z Lu, J Bohn, R Bergeron, Q Deng, KP Ellsworth, WM Geissler, G Harris, ... Bioorganic & medicinal chemistry letters 13 (22), 4125-4128, 2003 | 51 | 2003 |
Discovery of MK-8722: a systemic, direct pan-activator of AMP-activated protein kinase D Feng, T Biftu, FA Romero, A Kekec, J Dropinski, A Kassick, S Xu, ... ACS medicinal chemistry letters 9 (1), 39-44, 2018 | 44 | 2018 |