Extended spectrum of idiopathic generalized epilepsies associated with CACNA1H functional variants SE Heron, H Khosravani, D Varela, C Bladen, TC Williams, MR Newman, ... Annals of Neurology: Official Journal of the American Neurological …, 2007 | 248 | 2007 |
NAD (P) H oxidase-derived H2O2 signals chloride channel activation in cell volume regulation and cell proliferation D Varela, F Simon, A Riveros, F Jørgensen, A Stutzin Journal of Biological Chemistry 279 (14), 13301-13304, 2004 | 166 | 2004 |
D1 receptors physically interact with N-type calcium channels to regulate channel distribution and dendritic calcium entry AE Kisilevsky, SJ Mulligan, C Altier, MC Iftinca, D Varela, C Tai, L Chen, ... Neuron 58 (4), 557-570, 2008 | 152 | 2008 |
Sarcopenia and androgens: a link between pathology and treatment C Basualto-Alarcón, D Varela, J Duran, R Maass, M Estrada Frontiers in endocrinology 5, 116787, 2014 | 114 | 2014 |
Regulation of T-type calcium channels by Rho-associated kinase M Iftinca, J Hamid, L Chen, D Varela, R Tadayonnejad, C Altier, ... Nature neuroscience 10 (7), 854-860, 2007 | 103 | 2007 |
Transient receptor potential melastatin 4 inhibition prevents lipopolysaccharide-induced endothelial cell death A Becerra, C Echeverría, D Varela, D Sarmiento, R Armisen, ... Cardiovascular research 91 (4), 677-684, 2011 | 95 | 2011 |
The voltage‐dependent ClC‐2 chloride channel has a dual gating mechanism L Zúñiga, MI Niemeyer, D Varela, M Catalán, LP Cid, FV Sepúlveda The Journal of physiology 555 (3), 671-682, 2004 | 93 | 2004 |
Oxidative stress-modulated TRPM ion channels in cell dysfunction and pathological conditions in humans F Simon, D Varela, C Cabello-Verrugio Cellular signalling 25 (7), 1614-1624, 2013 | 91 | 2013 |
Hydrogen peroxide removes TRPM4 current desensitization conferring increased vulnerability to necrotic cell death F Simon, E Leiva-Salcedo, R Armisén, A Riveros, O Cerda, D Varela, ... Journal of biological chemistry 285 (48), 37150-37158, 2010 | 78 | 2010 |
TRPM4 is a novel component of the adhesome required for focal adhesion disassembly, migration and contractility M Cáceres, L Ortiz, T Recabarren, A Romero, A Colombo, ... PLoS One 10 (6), e0130540, 2015 | 65 | 2015 |
Effect of an N‐terminus deletion on voltage‐dependent gating of the ClC‐2 chloride channel D Varela, MI Niemeyer, LP Cid, FV Sepúlveda The Journal of physiology 544 (2), 363-372, 2002 | 54 | 2002 |
FR58P1a; a new uncoupler of OXPHOS that inhibits migration in triple-negative breast cancer cells via Sirt1/AMPK/β1-integrin pathway FA Urra, F Muñoz, M Córdova-Delgado, MP Ramírez, B Peña-Ahumada, ... Scientific reports 8 (1), 13190, 2018 | 51 | 2018 |
Increased expression of the transient receptor potential melastatin 7 channel is critically involved in lipopolysaccharide-induced reactive oxygen species-mediated neuronal death F Nunez-Villena, A Becerra, C Echeverría, N Briceno, O Porras, ... Antioxidants & Redox Signaling 15 (9), 2425-2438, 2011 | 50 | 2011 |
Increases in reactive oxygen species enhance vascular endothelial cell migration through a mechanism dependent on the transient receptor potential melastatin 4 ion channel D Sarmiento, I Montorfano, O Cerda, M Cáceres, A Becerra, ... Microvascular research 98, 187-196, 2015 | 47 | 2015 |
Excessive release of inorganic polyphosphate by ALS/FTD astrocytes causes non-cell-autonomous toxicity to motoneurons C Arredondo, C Cefaliello, A Dyrda, N Jury, P Martinez, I Díaz, A Amaro, ... Neuron 110 (10), 1656-1670. e12, 2022 | 42 | 2022 |
Endotoxin induces fibrosis in vascular endothelial cells through a mechanism dependent on transient receptor protein melastatin 7 activity C Echeverría, I Montorfano, T Hermosilla, R Armisén, LA Velásquez, ... PLoS One 9 (4), e94146, 2014 | 42 | 2014 |
Hydroxyl radical activation of a Ca2+-sensitive nonselective cation channel involved in epithelial cell necrosis F Simon, D Varela, AL Eguiguren, LF Díaz, F Sala, A Stutzin American Journal of Physiology-Cell Physiology 287 (4), C963-C970, 2004 | 41 | 2004 |
OxHDL controls LOX-1 expression and plasma membrane localization through a mechanism dependent on NOX/ROS/NF-κB pathway on endothelial cells L Pérez, A Vallejos, C Echeverria, D Varela, C Cabello-Verrugio, F Simon Laboratory Investigation 99 (3), 421-437, 2019 | 40 | 2019 |
Targeting the transient receptor potential vanilloid type 1 (TRPV1) assembly domain attenuates inflammation-induced hypersensitivity R Flynn, K Chapman, M Iftinca, R Aboushousha, D Varela, C Altier Journal of Biological Chemistry 289 (24), 16675-16687, 2014 | 39 | 2014 |
Activation of H2O2-Induced VSOR Cl- Currents in HTC Cells Require Phospholipase Cγ1 Phosphorylation and Ca2+ Mobilisation D Varela, F Simon, P Olivero, R Armisén, E Leiva-Salcedo, F Jørgensen, ... Cellular Physiology and Biochemistry 20 (6), 773-780, 2007 | 39 | 2007 |