M. Margarida Bernardo
M. Margarida Bernardo
Scientist-Project Manager, WSU School of Medicine, Karmanos Cancer Institute
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Binding of active (57 kDa) membrane type 1-matrix metalloproteinase (MT1-MMP) to tissue inhibitor of metalloproteinase (TIMP)-2 regulates MT1-MMP processing and pro-MMP-2 …
S Hernandez-Barrantes, M Toth, MM Bernardo, M Yurkova, DC Gervasi, ...
Journal of Biological Chemistry 275 (16), 12080-12089, 2000
Pro-MMP-9 activation by the MT1-MMP/MMP-2 axis and MMP-3: role of TIMP-2 and plasma membranes
M Toth, I Chvyrkova, MM Bernardo, S Hernandez-Barrantes, R Fridman
Biochemical and biophysical research communications 308 (2), 386-395, 2003
Potent and selective mechanism-based inhibition of gelatinases
S Brown, MM Bernardo, ZH Li, LP Kotra, Y Tanaka, R Fridman, ...
Journal of the American Chemical Society 122 (28), 6799-6800, 2000
TIMP-2 (tissue inhibitor of metalloproteinase-2) regulates MMP-2 (matrix metalloproteinase-2) activity in the extracellular environment after pro-MMP-2 activation by MT1 …
MM Bernardo, R Fridman
Biochemical journal 374 (3), 739-745, 2003
Tissue inhibitor of metalloproteinase-1 protects human breast epithelial cells against intrinsic apoptotic cell death via the focal adhesion kinase/phosphatidylinositol 3 …
XW Liu, MM Bernardo, R Fridman, HRC Kim
Journal of Biological Chemistry 278 (41), 40364-40372, 2003
Regulation of membrane type-matrix metalloproteinases
S Hernandez-Barrantes, M Bernardo, M Toth, R Fridman
Seminars in cancer biology 12 (2), 131-138, 2002
Characterization of the monomeric and dimeric forms of latent and active matrix metalloproteinase-9: differential rates for activation by stromelysin 1
MW Olson, MM Bernardo, M Pietila, DC Gervasi, M Toth, LP Kotra, ...
Journal of Biological Chemistry 275 (4), 2661-2668, 2000
Turning subjective into objective: the BCCT. core software for evaluation of cosmetic results in breast cancer conservative treatment
MJ Cardoso, J Cardoso, N Amaral, I Azevedo, L Barreau, M Bernardo, ...
The Breast 16 (5), 456-461, 2007
Differential inhibition of membrane type 3 (MT3)-matrix metalloproteinase (MMP) and MT1-MMP by tissue inhibitor of metalloproteinase (TIMP)-2 and TIMP-3 regulates pro-MMP-2 …
H Zhao, MM Bernardo, P Osenkowski, A Sohail, D Pei, H Nagase, ...
Journal of Biological Chemistry 279 (10), 8592-8601, 2004
Tissue inhibitor of metalloproteinase (TIMP)-2 acts synergistically with synthetic matrix metalloproteinase (MMP) inhibitors but not with TIMP-4 to enhance the (Membrane type 1 …
M Toth, MM Bernardo, DC Gervasi, PD Soloway, Z Wang, HF Bigg, ...
Journal of Biological Chemistry 275 (52), 41415-41423, 2000
Antimetastatic activity of a novel mechanism-based gelatinase inhibitor
A Krüger, MJE Arlt, M Gerg, C Kopitz, MM Bernardo, M Chang, ...
Cancer research 65 (9), 3523-3526, 2005
MT4-(MMP17) and MT6-MMP (MMP25), A unique set of membrane-anchored matrix metalloproteinases: properties and expression in cancer
A Sohail, Q Sun, H Zhao, MM Bernardo, JA Cho, R Fridman
Cancer and Metastasis reviews 27, 289-302, 2008
Potent mechanism-based inhibitors for matrix metalloproteinases
M Ikejiri, MM Bernardo, RD Bonfil, M Toth, M Chang, R Fridman, ...
Journal of Biological Chemistry 280 (40), 33992-34002, 2005
Complex pattern of membrane type 1 matrix metalloproteinase shedding: regulation by autocatalytic cell surface inactivation of active enzyme
M Toth, S Hernandez-Barrantes, P Osenkowski, MM Bernardo, ...
Journal of Biological Chemistry 277 (29), 26340-26350, 2002
Matrix metalloproteinase activity and osteoclasts in experimental prostate cancer bone metastasis tissue
Z Dong, RD Bonfil, S Chinni, X Deng, JC Trindade Filho, M Bernardo, ...
The American journal of pathology 166 (4), 1173-1186, 2005
Mucinous carcinoma of the breast: a pathologic study of 82 cases
S André, F Cunha, J Soares, M Bernardo, JM E Sousa, F Cortez
Journal of surgical oncology 58 (3), 162-167, 1995
Comparison of the influence of saturated nitrogen and sulfur donor atoms on the properties of copper (II/I)-macrocyclic polyamino polythiaether ligand complexes: redox …
MM Bernardo, MJ Heeg, RR Schroeder, LA Ochrymowycz, ...
Inorganic Chemistry 31 (2), 191-198, 1992
X-ray absorption studies of human matrix metalloproteinase-2 (MMP-2) bound to a highly selective mechanism-based inhibitor: Comparison with the latent and active forms of the …
O Kleifeld, LP Kotra, DC Gervasi, S Brown, MM Bernardo, R Fridman, ...
Journal of Biological Chemistry 276 (20), 17125-17131, 2001
Design, synthesis, and characterization of potent, slow-binding inhibitors that are selective for gelatinases
MM Bernardo, S Brown, ZH Li, R Fridman, S Mobashery
Journal of Biological Chemistry 277 (13), 11201-11207, 2002
Inhibition of human prostate cancer growth, osteolysis and angiogenesis in a bone metastasis model by a novel mechanism‐based selective gelatinase inhibitor
RD Bonfil, A Sabbota, S Nabha, MM Bernardo, Z Dong, H Meng, ...
International journal of cancer 118 (11), 2721-2726, 2006
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