|EZH2 oncogenic activity in castration-resistant prostate cancer cells is Polycomb-independent|
K Xu, ZJ Wu, AC Groner, HH He, C Cai, RT Lis, X Wu, EC Stack, M Loda, ...
Science 338 (6113), 1465-1469, 2012
|Intratumoral De Novo Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 InhibitorsProstate …|
C Cai, S Chen, P Ng, GJ Bubley, PS Nelson, EA Mostaghel, B Marck, ...
Cancer research 71 (20), 6503-6513, 2011
|Androgen receptor gene expression in prostate cancer is directly suppressed by the androgen receptor through recruitment of lysine-specific demethylase 1|
C Cai, HH He, S Chen, I Coleman, H Wang, Z Fang, S Chen, PS Nelson, ...
Cancer cell 20 (4), 457-471, 2011
|Androgen receptor functions in castration-resistant prostate cancer and mechanisms of resistance to new agents targeting the androgen axis|
X Yuan, C Cai, S Chen, Z Yu, SP Balk
Oncogene 33 (22), 2815-2825, 2014
|Rapid Induction of Androgen Receptor Splice Variants by Androgen Deprivation in Prostate CancerAndrogen Repression of AR Splice Variant|
Z Yu, S Chen, AG Sowalsky, OS Voznesensky, EA Mostaghel, PS Nelson, ...
Clinical cancer research 20 (6), 1590-1600, 2014
|Intratumoral androgen biosynthesis in prostate cancer pathogenesis and response to therapy|
C Cai, SP Balk
Endocrine-related cancer 18 (5), 2011
|ERG induces androgen receptor-mediated regulation of SOX9 in prostate cancer|
C Cai, H Wang, HH He, S Chen, L He, F Ma, L Mucci, Q Wang, C Fiore, ...
The Journal of clinical investigation 123 (3), 1109-1122, 2013
|Abiraterone Treatment in Castration-Resistant Prostate Cancer Selects for Progesterone Responsive Mutant Androgen ReceptorsAbiraterone-Driven AR Mutations|
EJ Chen, AG Sowalsky, S Gao, C Cai, O Voznesensky, R Schaefer, ...
Clinical cancer research 21 (6), 1273-1280, 2015
|Reactivation of Androgen Receptor–Regulated TMPRSS2: ERG Gene Expression in Castration-Resistant Prostate Cancer|
C Cai, H Wang, Y Xu, S Chen, SP Balk
Cancer research 69 (15), 6027-6032, 2009
|SOX9 drives WNT pathway activation in prostate cancer|
F Ma, H Ye, HH He, SJ Gerrin, S Chen, BA Tanenbaum, C Cai, ...
The Journal of clinical investigation 126 (5), 1745-1758, 2016
|ETV1 is a novel androgen receptor-regulated gene that mediates prostate cancer cell invasion|
C Cai, CL Hsieh, J Omwancha, Z Zheng, SY Chen, JL Baert, ...
Molecular endocrinology 21 (8), 1835-1846, 2007
|Lysine-specific demethylase 1 has dual functions as a major regulator of androgen receptor transcriptional activity|
C Cai, HH He, S Gao, S Chen, Z Yu, Y Gao, S Chen, MW Chen, J Zhang, ...
Cell reports 9 (5), 1618-1627, 2014
|Androgen receptor serine 81 phosphorylation mediates chromatin binding and transcriptional activation|
S Chen, S Gulla, C Cai, SP Balk
Journal of Biological Chemistry 287 (11), 8571-8583, 2012
|Galeterone Prevents Androgen Receptor Binding to Chromatin and Enhances Degradation of Mutant Androgen ReceptorGaleterone Actions as AR Antagonist|
Z Yu, C Cai, S Gao, NI Simon, HC Shen, SP Balk
Clinical Cancer Research 20 (15), 4075-4085, 2014
|Androgen receptor enhances p27 degradation in prostate cancer cells through rapid and selective TORC2 activation|
Z Fang, T Zhang, N Dizeyi, S Chen, H Wang, KD Swanson, C Cai, ...
Journal of Biological Chemistry 287 (3), 2090-2098, 2012
|Androgen receptor tumor suppressor function is mediated by recruitment of retinoblastoma protein|
S Gao, Y Gao, HH He, D Han, W Han, A Avery, JA Macoska, X Liu, ...
Cell reports 17 (4), 966-976, 2016
|c-Jun enhancement of androgen receptor transactivation is associated with prostate cancer cell proliferation|
SY Chen, C Cai, CJ Fisher, Z Zheng, J Omwancha, CL Hsieh, ...
Oncogene 25 (54), 7212-7223, 2006
|Reactivation of androgen receptor-regulated lipid biosynthesis drives the progression of castration-resistant prostate cancer|
W Han, S Gao, D Barrett, M Ahmed, D Han, JA Macoska, HH He, C Cai
Oncogene 37 (6), 710-721, 2018
|LSD1-Mediated Epigenetic Reprogramming Drives CENPE Expression and Prostate Cancer ProgressionCENPE Is a Therapeutic Target for CRPC|
Y Liang, M Ahmed, H Guo, F Soares, JT Hua, S Gao, C Lu, C Poon, ...
Cancer research 77 (20), 5479-5490, 2017
|Androgen induces expression of the multidrug resistance protein gene MRP4 in prostate cancer cells|
C Cai, J Omwancha, CL Hsieh, L Shemshedini
Prostate cancer and prostatic diseases 10 (1), 39-45, 2007