William Beltran
William Beltran
Professor of Ophthalmology- University of Pennsylvania
Verified email at vet.upenn.edu - Homepage
Title
Cited by
Cited by
Year
Human retinal gene therapy for Leber congenital amaurosis shows advancing retinal degeneration despite enduring visual improvement
AV Cideciyan, SG Jacobson, WA Beltran, A Sumaroka, M Swider, S Iwabe, ...
Proceedings of the National Academy of Sciences 110 (6), E517-E525, 2013
3742013
Gene therapy rescues photoreceptor blindness in dogs and paves the way for treating human X-linked retinitis pigmentosa
WA Beltran, AV Cideciyan, AS Lewin, S Iwabe, H Khanna, A Sumaroka, ...
Proceedings of the National Academy of Sciences 109 (6), 2132-2137, 2012
2432012
Human cone photoreceptor dependence on RPE65 isomerase
SG Jacobson, TS Aleman, AV Cideciyan, E Heon, M Golczak, WA Beltran, ...
Proceedings of the National Academy of Sciences 104 (38), 15123-15128, 2007
1312007
A frameshift mutation in RPGR exon ORF15 causes photoreceptor degeneration and inner retina remodeling in a model of X-linked retinitis pigmentosa
WA Beltran, P Hammond, GM Acland, GD Aguirre
Investigative ophthalmology & visual science 47 (4), 1669-1681, 2006
1052006
Restoration of visual function by expression of a light-gated mammalian ion channel in retinal ganglion cells or ON-bipolar cells
BM Gaub, MH Berry, AE Holt, A Reiner, MA Kienzler, N Dolgova, ...
Proceedings of the National Academy of Sciences 111 (51), E5574-E5583, 2014
832014
Canine retina has a primate fovea-like bouquet of cone photoreceptors which is affected by inherited macular degenerations
WA Beltran, AV Cideciyan, KE Guziewicz, S Iwabe, M Swider, EM Scott, ...
PloS one 9 (3), e90390, 2014
832014
rAAV2/5 gene-targeting to rods: dose-dependent efficiency and complications associated with different promoters
WA Beltran, SL Boye, SE Boye, VA Chiodo, AS Lewin, WW Hauswirth, ...
Gene therapy 17 (9), 1162-1174, 2010
652010
Immunolocalization of ciliary neurotrophic factor receptor α (CNTFRα) in mammalian photoreceptor cells
W Beltran, H Rohrer, GD Aguirre
Molecular vision 11, 232, 2005
632005
Transient photoreceptor deconstruction by CNTF enhances rAAV-mediated cone functional rescue in late stage CNGB3-achromatopsia
AM Komáromy, JS Rowlan, ATP Corr, SL Reinstein, SL Boye, AE Cooper, ...
Molecular Therapy 21 (6), 1131-1141, 2013
572013
Cloning, mapping, and retinal expression of the canine ciliary neurotrophic factor receptor α (CNTFRα)
WA Beltran, Q Zhang, JW Kijas, D Gu, H Rohrer, JA Jordan, GD Aguirre
Investigative ophthalmology & visual science 44 (8), 3642-3649, 2003
552003
Successful arrest of photoreceptor and vision loss expands the therapeutic window of retinal gene therapy to later stages of disease
WA Beltran, AV Cideciyan, S Iwabe, M Swider, MS Kosyk, K McDaid, ...
Proceedings of the National Academy of Sciences 112 (43), E5844-E5853, 2015
542015
Optimization of retinal gene therapy for X-linked retinitis pigmentosa due to RPGR mutations
WA Beltran, AV Cideciyan, SE Boye, GJ Ye, S Iwabe, VL Dufour, ...
Molecular Therapy 25 (8), 1866-1880, 2017
452017
Recombinant AAV-mediated BEST1 transfer to the retinal pigment epithelium: analysis of serotype-dependent retinal effects
KE Guziewicz, B Zangerl, AM Komáromy, S Iwabe, VA Chiodo, SL Boye, ...
PLoS One 8 (10), e75666, 2013
452013
The use of canine models of inherited retinal degeneration to test novel therapeutic approaches
WA Beltran
Veterinary ophthalmology 12 (3), 192-204, 2009
452009
Intravitreal injection of ciliary neurotrophic factor (CNTF) causes peripheral remodeling and does not prevent photoreceptor loss in canine RPGR mutant retina
WA Beltran, R Wen, GM Acland, GD Aguirre
Experimental eye research 84 (4), 753-771, 2007
442007
Bestrophinopathy is an RPE-photoreceptor interface disease
KE Guziewicz, WA Beltran, S Iwabe, AV Cideciyan, SG Jacobson, ...
Investigative Ophthalmology & Visual Science 57 (12), 2016
392016
Photoreceptor cell death, proliferation and formation of hybrid rod/S-cone photoreceptors in the degenerating STK38L mutant retina
ÁI Berta, K Boesze-Battaglia, S Genini, O Goldstein, PJ O'Brien, Á Szél, ...
PLoS One 6 (9), e24074, 2011
342011
Age-dependent disease expression determines remodeling of the retinal mosaic in carriers of RPGR exon ORF15 mutations
WA Beltran, GM Acland, GD Aguirre
Investigative ophthalmology & visual science 50 (8), 3985-3995, 2009
322009
Ocular findings in two colonies of gray mouse lemurs (Microcebus murinus)
WA Beltran, M Vanore, F Ollivet, F Nemoz‐Bertholet, F Aujard, B Clerc, ...
Veterinary ophthalmology 10 (1), 43-49, 2007
322007
Adenovirus‐mediated gene transfer in canine eyes: a preclinical study for gene therapy of human uveal melanoma
M Andrawiss, A Maron, W Beltran, P Opolon, E Connault, F Griscelli, ...
The journal of gene medicine 3 (3), 228-239, 2001
302001
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