Structure of the core of the type III secretion system export apparatus L Kuhlen, P Abrusci, S Johnson, J Gault, J Deme, J Caesar, T Dietsche, ... Nature structural & molecular biology 25 (7), 583-590, 2018 | 175 | 2018 |
Type 9 secretion system structures reveal a new protein transport mechanism F Lauber, JC Deme, SM Lea, BC Berks Nature 564 (7734), 77-82, 2018 | 149 | 2018 |
Structures of the stator complex that drives rotation of the bacterial flagellum JC Deme, S Johnson, O Vickery, A Aron, H Monkhouse, T Griffiths, ... Nature Microbiology 5 (12), 1553-1564, 2020 | 139 | 2020 |
Molecular basis for redox control by the human cystine/glutamate antiporter system xc− JL Parker, JC Deme, D Kolokouris, G Kuteyi, PC Biggin, SM Lea, ... Nature communications 12 (1), 7147, 2021 | 85 | 2021 |
Molecular structure of the intact bacterial flagellar basal body S Johnson, EJ Furlong, JC Deme, AL Nord, JJE Caesar, FFV Chevance, ... Nature microbiology 6 (6), 712-721, 2021 | 64 | 2021 |
Symmetry mismatch in the MS-ring of the bacterial flagellar rotor explains the structural coordination of secretion and rotation S Johnson, YH Fong, JC Deme, EJ Furlong, L Kuhlen, SM Lea Nature Microbiology 5 (7), 966-975, 2020 | 62 | 2020 |
The substrate specificity switch FlhB assembles onto the export gate to regulate type three secretion L Kuhlen, S Johnson, A Zeitler, S Bäurle, JC Deme, JJE Caesar, R Debo, ... Nature communications 11 (1), 1296, 2020 | 61 | 2020 |
The structure of an injectisome export gate demonstrates conservation of architecture in the core export gate between flagellar and virulence type III secretion systems S Johnson, L Kuhlen, JC Deme, P Abrusci, SM Lea MBio 10 (3), 10.1128/mbio. 00818-19, 2019 | 54 | 2019 |
Structure and mechanism of the proton-driven motor that powers type 9 secretion and gliding motility R Hennell James, JC Deme, A Kjӕr, F Alcock, A Silale, F Lauber, ... Nature microbiology 6 (2), 221-233, 2021 | 53 | 2021 |
Structural basis of antifolate recognition and transport by PCFT JL Parker, JC Deme, G Kuteyi, Z Wu, J Huo, ID Goldman, RJ Owens, ... Nature 595 (7865), 130-134, 2021 | 48 | 2021 |
Mechanism of lipid droplet formation by the yeast Sei1/Ldb16 Seipin complex YA Klug, JC Deme, RA Corey, MF Renne, PJ Stansfeld, SM Lea, ... Nature communications 12 (1), 5892, 2021 | 46 | 2021 |
Purification and interaction analyses of two human lysosomal vitamin B12 transporters: LMBD1 and ABCD4 JC Deme, MA Hancock, X Xia, CA Shintre, M Plesa, JC Kim, ... Molecular membrane biology 31 (7-8), 250-261, 2014 | 43 | 2014 |
SIMPLE 3.0. Stream single-particle cryo-EM analysis in real time J Caesar, CF Reboul, C Machello, S Kiesewetter, ML Tang, JC Deme, ... Journal of structural biology: X 4, 100040, 2020 | 42 | 2020 |
Cryo-EM structure of PepT2 reveals structural basis for proton-coupled peptide and prodrug transport in mammals JL Parker, JC Deme, Z Wu, G Kuteyi, J Huo, RJ Owens, PC Biggin, ... Science advances 7 (35), eabh3355, 2021 | 35 | 2021 |
Subcellular location of MMACHC and MMADHC, two human proteins central to intracellular vitamin B12 metabolism W Mah, JC Deme, D Watkins, S Fung, A Janer, EA Shoubridge, ... Molecular genetics and metabolism 108 (2), 112-118, 2013 | 35 | 2013 |
Cryo-EM structure and resistance landscape of M. tuberculosis MmpL3: An emergent therapeutic target O Adams, JC Deme, JL Parker, PW Fowler, SM Lea, S Newstead Structure 29 (10), 1182-1191. e4, 2021 | 33 | 2021 |
A signal sequence suppressor mutant that stabilizes an assembled state of the twin arginine translocase Q Huang, F Alcock, H Kneuper, JC Deme, SE Rollauer, SM Lea, BC Berks, ... Proceedings of the National Academy of Sciences 114 (10), E1958-E1967, 2017 | 31 | 2017 |
Structural features of recombinant MMADHC isoforms and their interactions with MMACHC, proteins of mammalian vitamin B12 metabolism JC Deme, IR Miousse, M Plesa, JC Kim, MA Hancock, W Mah, ... Molecular genetics and metabolism 107 (3), 352-362, 2012 | 31 | 2012 |
Membrane Protein Complex ExbB4-ExbD1-TonB1 from Escherichia coli Demonstrates Conformational Plasticity A Sverzhinsky, JW Chung, JC Deme, L Fabre, KT Levey, M Plesa, ... Journal of bacteriology 197 (11), 1873-1885, 2015 | 27 | 2015 |
Huntingtin structure is orchestrated by HAP40 and shows a polyglutamine expansion-specific interaction with exon 1 RJ Harding, JC Deme, JF Hevler, S Tamara, A Lemak, JP Cantle, ... Communications Biology 4 (1), 1374, 2021 | 26 | 2021 |