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Denis Titov
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XPB, a subunit of TFIIH, is a target of the natural product triptolide
DV Titov, B Gilman, QL He, S Bhat, WK Low, Y Dang, M Smeaton, ...
Nature chemical biology 7 (3), 182-188, 2011
5042011
Complementation of mitochondrial electron transport chain by manipulation of the NAD+/NADH ratio
DV Titov, V Cracan, RP Goodman, J Peng, Z Grabarek, VK Mootha
Science 352 (6282), 231-235, 2016
3902016
Distinct mitochondrial defects trigger the integrated stress response depending on the metabolic state of the cell
E Mick, DV Titov, OS Skinner, R Sharma, AA Jourdain, VK Mootha
elife 9, e49178, 2020
1822020
A cellular mechanism to detect and alleviate reductive stress
AG Manford, F Rodríguez-Pérez, KY Shih, Z Shi, CA Berdan, M Choe, ...
Cell 183 (1), 46-61. e21, 2020
1282020
Homozygous deletion in MICU1 presenting with fatigue and lethargy in childhood
D Lewis-Smith, KJ Kamer, H Griffin, AM Childs, K Pysden, D Titov, J Duff, ...
Neurology: Genetics 2 (2), e59, 2016
1082016
Analyzing protein kinase dynamics in living cells with FRET reporters
Q Ni, DV Titov, J Zhang
Methods 40 (3), 279-286, 2006
1022006
A genetically encoded tool for manipulation of NADP+/NADPH in living cells
V Cracan, DV Titov, H Shen, Z Grabarek, VK Mootha
Nature chemical biology 13 (10), 1088-1095, 2017
982017
Physical bioenergetics: Energy fluxes, budgets, and constraints in cells
X Yang, M Heinemann, J Howard, G Huber, S Iyer-Biswas, G Le Treut, ...
Proceedings of the National Academy of Sciences 118 (26), e2026786118, 2021
922021
Covalent modification of a cysteine residue in the XPB subunit of the general transcription factor TFIIH through single epoxide cleavage of the transcription inhibitor triptolide
QL He, DV Titov, J Li, M Tan, Z Ye, Y Zhao, D Romo, JO Liu
Angewandte Chemie International Edition 54 (6), 1859-1863, 2015
902015
Identification and validation of protein targets of bioactive small molecules
DV Titov, JO Liu
Bioorganic & medicinal chemistry 20 (6), 1902-1909, 2012
572012
Genetically encoded tools for measuring and manipulating metabolism
M Choe, DV Titov
Nature chemical biology 18 (5), 451-460, 2022
252022
Listeria monocytogenes requires cellular respiration for NAD+ regeneration and pathogenesis
R Rivera-Lugo, D Deng, A Anaya-Sanchez, S Tejedor-Sanz, E Tang, ...
Elife 11, e75424, 2022
212022
The Warburg Effect is the result of faster ATP production by glycolysis than respiration
MA Kukurugya, DV Titov
BioRxiv, 2022.12. 28.522160, 2022
62022
Regulator of Ras depalmitoylation and retrograde trafficking: a new hat for FKBP
JO Liu, DV Titov, Y Dang, Q He
Molecular cell 41 (2), 131-133, 2011
32011
Genetically encoded tool for manipulation of ΔΨm identifies the latter as the driver of integrative stress response induced by ATP Synthase dysfunction
M Choe, DV Titov
bioRxiv, 2023
12023
Mechanism of action of the antiproliferative natural product triptolide
DV Titov
The Johns Hopkins University, 2012
12012
Protein prostheses for mitochondrial diseases or conditions
V Mootha, D Titov, V Cracan, Z Grabarek
US Patent App. 18/516,366, 2024
2024
Protein prostheses for mitochondrial diseases or conditions
V Mootha, D Titov, V Cracan, Z Grabarek
US Patent 11,866,736, 2024
2024
Data-driven model of glycolysis identifies the role of allostery in maintaining ATP homeostasis
M Choe, T Einav, R Phillips, DV Titov
bioRxiv, 2022.12. 28.522046, 2022
2022
Genetically Encoded Tools for Compartment-Specific Manipulation of NAD+/NADH or NADP+/NADPH Ratios
V Cracan, D Titov, Z Grabarek, V Mootha
Free Radical Biology and Medicine 100, S182, 2016
2016
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Articles 1–20