Daksh Thaper
Daksh Thaper
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The master neural transcription factor BRN2 is an androgen receptor suppressed driver of neuroendocrine differentiation in prostate cancer
JL Bishop, D Thaper, S Vahid, A Davies, K Ketola, H Kuruma, R Jama, ...
Cancer discovery, CD-15-1263, 2017
Synergistic Targeting of PI3K/AKT Pathway and Androgen Receptor Axis Significantly Delays Castration-Resistant Prostate Cancer Progression In VivoTargeting AKT Pathway and AR …
C Thomas, F Lamoureux, C Crafter, BR Davies, E Beraldi, L Fazli, S Kim, ...
Molecular cancer therapeutics 12 (11), 2342-2355, 2013
The multifaceted roles of STAT3 signaling in the progression of prostate cancer
JL Bishop, D Thaper, A Zoubeidi
Cancers 6 (2), 829-859, 2014
The master neural transcription factor BRN2 is an androgen receptor-suppressed driver of neuroendocrine differentiation in prostate cancer. Cancer Discov. 2017; 7: 54–71. doi …
JL Bishop, D Thaper, S Vahid, A Davies, K Ketola, H Kuruma, R Jama, ...
This works provides a mechanistic model for neuroendocrine differentiation …, 0
Hsp27 regulates EGF/β‐catenin mediated epithelial to mesenchymal transition in prostate cancer
T Cordonnier, JL Bishop, M Shiota, KM Nip, D Thaper, S Vahid, D Heroux, ...
International Journal of Cancer 136 (6), E496-E507, 2015
Insulin-like growth factor-I induces CLU expression through Twist1 to promote prostate cancer growth
A Takeuchi, M Shiota, E Beraldi, D Thaper, K Takahara, N Ibuki, M Pollak, ...
Molecular and cellular endocrinology 384 (1-2), 117-125, 2014
Molecular chaperone Hsp27 regulates the Hippo tumor suppressor pathway in cancer
S Vahid, D Thaper, KF Gibson, JL Bishop, A Zoubeidi
Scientific reports 6 (1), 1-12, 2016
An androgen receptor switch underlies lineage infidelity in treatment-resistant prostate cancer
A Davies, S Nouruzi, D Ganguli, T Namekawa, D Thaper, S Linder, ...
Nature cell biology 23 (9), 1023-1034, 2021
SEMA 3C drives cancer growth by transactivating multiple receptor tyrosine kinases via Plexin B1
JW Peacock, A Takeuchi, N Hayashi, L Liu, KJ Tam, N Al Nakouzi, ...
EMBO molecular medicine 10 (2), 219-238, 2018
Lyn tyrosine kinase regulates androgen receptor expression and activity in castrate-resistant prostate cancer
A Zardan, KM Nip, D Thaper, P Toren, S Vahid, E Beraldi, L Fazli, ...
Oncogenesis 3 (8), e115-e115, 2014
Galiellalactone inhibits the STAT3/AR signaling axis and suppresses Enzalutamide-resistant Prostate Cancer
D Thaper, S Vahid, R Kaur, S Kumar, S Nouruzi, JL Bishop, M Johansson, ...
Scientific reports 8 (1), 1-9, 2018
Targeting Lyn regulates Snail family shuttling and inhibits metastasis
D Thaper, S Vahid, KM Nip, I Moskalev, X Shan, S Frees, ME Roberts, ...
Oncogene 36 (28), 3964-3975, 2017
PEG10 is associated with treatment-induced neuroendocrine prostate cancer
S Kim, D Thaper, S Bidnur, P Toren, S Akamatsu, JL Bishop, C Colins, ...
Journal of Molecular Endocrinology 63 (1), 39-49, 2019
Chaperoning the cancer: the proteostatic functions of the heat shock proteins in cancer
S Vahid, D Thaper, A Zoubeidi
Recent Patents on Anti-Cancer Drug Discovery 12 (1), 35-47, 2017
ASCL1 activates neuronal stem cell-like lineage programming through remodeling of the chromatin landscape in prostate cancer
S Nouruzi, D Ganguli, N Tabrizian, M Kobelev, O Sivak, T Namekawa, ...
Nature Communications 13 (1), 2282, 2022
First-in-field small molecule inhibitors targeting BRN2 as a therapeutic strategy for small cell prostate cancer
D Thaper, R Munuganti, S Nouruzi, S Kumar, S Kim, O Sivak, A Aguda, ...
Cancer Research 79 (13_Supplement), 1295-1295, 2019
Reduction in PD-L1 expression by STAT3 inhibition with GPA500 in enzalutamide-resistant prosate cancer.
JL Bishop, DL Thaper, S Vaheid, MH Johansson, A Zoubeidi
Journal of Clinical Oncology 33 (15_suppl), e16075-e16075, 2015
Neural transcription factors in disease progression
D Thaper, S Vahid, A Zoubeidi
Prostate Cancer: Cellular and Genetic Mechanisms of Disease Development and …, 2019
Genome-wide CRISPR screen reveals SLFN11 as a potent mediator of cisplatin sensitivity in muscle-invasive bladder cancer
G Kumar, E Ritch, HZ Oo, CK Wang, D Tortora, D Thaper, I Moskalev, ...
Urologic Oncology: Seminars and Original Investigations 38 (12), 905, 2020
New derivative of galiellalactone inhibits the STAT3 activity and suppresses ENZ-resistant Prostate Cancer in vitro
D Thaper, S Vahid, JL Bishop, M Johansson, A Zoubeidi
Cancer Research 75 (15_Supplement), 728-728, 2015
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