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Prof. Dr. Sevki Adem
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Identification of potent COVID-19 main protease (Mpro) inhibitors from natural polyphenols: an in silico strategy unveils a hope against CORONA
S Adem, V Eyupoglu, I Sarfraz, A Rasul, M Ali
Preprints 2020 (2020030333.10), 20944, 2020
2562020
Caffeic acid derivatives (CAFDs) as inhibitors of SARS-CoV-2: CAFDs-based functional foods as a potential alternative approach to combat COVID-19
Ş Adem, V Eyupoglu, I Sarfraz, A Rasul, AF Zahoor, M Ali, M Abdalla, ...
Phytomedicine 85, 153310, 2021
1192021
Synthesis, spectroscopic characterizations, enzyme inhibition, molecular docking study and DFT calculations of new Schiff bases of sulfa drugs
S Alyar, T Şen, ÜÖ Özmen, H Alyar, Ş Adem, C Şen
Journal of Molecular Structure 1185, 416-424, 2019
622019
Ginkgetin: A natural biflavone with versatile pharmacological activities
M Adnan, A Rasul, G Hussain, MA Shah, MK Zahoor, H Anwar, I Sarfraz, ...
Food and Chemical Toxicology 145, 111642, 2020
602020
Purification of rat kidney glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, and glutathione reductase enzymes using 2′, 5′-ADP Sepharose 4B affinity in a …
S Adem, M Ciftci
Protein Expression and Purification 81 (1), 1-4, 2012
522012
Synthesis, spectroscopic characterizations, carbonic anhydrase II inhibitory activity, anticancer activity and docking studies of new Schiff bases of sulfa drugs
S Alyar, ÜÖ Özmen, Ş Adem, H Alyar, E Bilen, K Kaya
Journal of Molecular Structure 1223, 128911, 2021
482021
Synthesis, characterization, antimicrobial activity, carbonic anhydrase enzyme inhibitor effects, and computational studies on new Schiff bases of Sulfa drugs and their Pd (II …
S Alyar, C Şen, H Alyar, Ş Adem, A Kalkanci, UO Ozdemir
Journal of Molecular Structure 1171, 214-222, 2018
452018
6-Phosphogluconate dehydrogenase fuels multiple aspects of cancer cells: from cancer initiation to metastasis and chemoresistance
I Sarfraz, A Rasul, G Hussain, MA Shah, FA Zahoor, M Asrar, Z Selamoglu, ...
BioFactors, 2020
422020
In vitro effects of some flavonoids and phenolic acids on human pyruvate kinase isoenzyme M2
E Aslan, C Guler, S Adem
Journal of enzyme inhibition and medicinal chemistry 31 (2), 314-317, 2016
392016
Hispolon: A natural polyphenol and emerging cancer killer by multiple cellular signaling pathways
A Sarfraz, A Rasul, I Sarfraz, MA Shah, G Hussain, N Shafiq, M Masood, ...
Environmental Research 190, 110017, 2020
382020
Investigation of the effects of some phenolic compounds on the Activities of glucose‐6‐phosphate dehydrogenase and 6‐Phosphogluconate dehydrogenase from human erythrocytes
S Adem, V Comakli, M Kuzu, R Demirdag
Journal of biochemical and molecular toxicology 28 (11), 510-514, 2014
372014
The isolation of secondary metabolites from Rheum ribes L. and the synthesis of new semi-synthetic anthraquinones: Isolation, synthesis and biological activity
IH Gecibesler, F Disli, S Bayindir, M Toprak, AR Tufekci, AS Yaglıoglu, ...
Food Chemistry 342, 128378, 2021
362021
Purification and biochemical characterization of glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase and glutathione reductase from rat lung and inhibition …
S Adem, M Ciftci
Journal of enzyme inhibition and medicinal chemistry 31 (6), 1342-1348, 2016
332016
Physcion and physcion 8-O-β-D-glucopyranoside: natural anthraquinones with potential anticancer activities
M Adnan, A Rasul, G Hussain, MA Shah, I Sarfraz, B Nageen, A Riaz, ...
Current Drug Targets 22 (5), 488-504, 2021
292021
Synthesis, characterization, antimicrobial activity and carbonic anhydrase enzyme inhibitor effects of salicilaldehyde-N-methyl p-toluenesulfonylhydrazone and its Palladium (II …
S Alyar, Ş Adem
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 131, 294-302, 2014
272014
In vitro effects of some flavones on human pyruvate kinase isoenzyme M2
E Aslan, S Adem
Journal of Biochemical and Molecular Toxicology 29 (3), 109-113, 2015
232015
Germacrone: A potent secondary metabolite with therapeutic potential in metabolic diseases, cancer and viral infections
A Riaz, A Rasul, N Kanwal, G Hussain, MA Shah, I Sarfraz, R Ishfaq, ...
Current Drug Metabolism 21 (14), 1079-1090, 2020
222020
Activation and inhibition effects of some natural products on human cytosolic CAI and CAII
S Adem, E Akkemik, H Aksit, P Guller, AR Tüfekci, İ Demirtas, M Ciftci
Medicinal Chemistry Research 28, 711-722, 2019
212019
Synthesis, characterization, molecular docking and in vitro screening of new metal complexes with coumarin Schiff base as anticholine esterase and antipancreatic cholesterol …
Ö Şahin, Ü Özmen Özdemir, N Seferoğlu, Ş Adem, Z Seferoğlu
Journal of Biomolecular Structure and Dynamics 40 (10), 4460-4474, 2022
202022
Multidimensional in silico strategy for identification of natural polyphenols-based SARS-CoV-2 main protease (Mpro) inhibitors to unveil a hope against COVID-19
Ş Adem, V Eyupoglu, IM Ibrahim, I Sarfraz, A Rasul, M Ali, AA Elfiky
Computers in biology and medicine 145, 105452, 2022
192022
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