Scott Yuzwa
Scott Yuzwa
Assistant Professor, University of Toronto
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A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo
SA Yuzwa, MS Macauley, JE Heinonen, X Shan, RJ Dennis, Y He, ...
Nature chemical biology 4 (8), 483-490, 2008
Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation
SA Yuzwa, X Shan, MS Macauley, T Clark, Y Skorobogatko, K Vosseller, ...
Nature chemical biology 8 (4), 393-399, 2012
The emerging link between O-GlcNAc and Alzheimer disease
Y Zhu, X Shan, SA Yuzwa, DJ Vocadlo
Journal of Biological Chemistry 289 (50), 34472-34481, 2014
O-GlcNAc and neurodegeneration: biochemical mechanisms and potential roles in Alzheimer's disease and beyond
SA Yuzwa, DJ Vocadlo
Chemical Society Reviews 43 (19), 6839-6858, 2014
Developmental emergence of adult neural stem cells as revealed by single-cell transcriptional profiling
SA Yuzwa, MJ Borrett, BT Innes, A Voronova, T Ketela, DR Kaplan, ...
Cell reports 21 (13), 3970-3986, 2017
Dedifferentiated Schwann cell precursors secreting paracrine factors are required for regeneration of the mammalian digit tip
APW Johnston, SA Yuzwa, MJ Carr, N Mahmud, MA Storer, MP Krause, ...
Cell stem cell 19 (4), 433-448, 2016
Mesenchymal precursor cells in adult nerves contribute to mammalian tissue repair and regeneration
MJ Carr, JS Toma, APW Johnston, PE Steadman, SA Yuzwa, N Mahmud, ...
Cell stem cell 24 (2), 240-256. e9, 2019
Mapping O-GlcNAc modification sites on tau and generation of a site-specific O-GlcNAc tau antibody
SA Yuzwa, AK Yadav, Y Skorobogatko, T Clark, K Vosseller, DJ Vocadlo
Amino acids 40, 857-868, 2011
O-GlcNAc modification of tau directly inhibits its aggregation without perturbing the conformational properties of tau monomers
SA Yuzwa, AH Cheung, M Okon, LP McIntosh, DJ Vocadlo
Journal of molecular biology 426 (8), 1736-1752, 2014
A translational repression complex in developing mammalian neural stem cells that regulates neuronal specification
SK Zahr, G Yang, H Kazan, MJ Borrett, SA Yuzwa, A Voronova, ...
Neuron 97 (3), 520-537. e6, 2018
Pharmacological inhibition of O-GlcNAcase (OGA) prevents cognitive decline and amyloid plaque formation in bigenic tau/APP mutant mice
SA Yuzwa, X Shan, BA Jones, G Zhao, ML Woodward, X Li, Y Zhu, ...
Molecular neurodegeneration 9 (1), 1-14, 2014
Insights into O-linked N-acetylglucosamine ([0-9] O-GlcNAc) processing and dynamics through kinetic analysis of O-GlcNAc transferase and O-GlcNAcase activity on protein substrates
DL Shen, TM Gloster, SA Yuzwa, DJ Vocadlo
Journal of Biological Chemistry 287 (19), 15395-15408, 2012
Elevation of Global O-GlcNAc in rodents using a selective O-GlcNAcase inhibitor does not cause insulin resistance or perturb glucohomeostasis
MS Macauley, X Shan, SA Yuzwa, TM Gloster, DJ Vocadlo
Chemistry & biology 17 (9), 949-958, 2010
Acquisition of a unique mesenchymal precursor-like blastema state underlies successful adult mammalian digit tip regeneration
MA Storer, N Mahmud, K Karamboulas, MJ Borrett, SA Yuzwa, A Gont, ...
Developmental cell 52 (4), 509-524. e9, 2020
Molecular basis for inhibition of GH84 glycoside hydrolases by substituted azepanes: conformational flexibility enables probing of substrate distortion
F Marcelo, Y He, SA Yuzwa, L Nieto, J Jiménez-Barbero, M Sollogoub, ...
Journal of the American Chemical Society 131 (15), 5390-5392, 2009
Migrating interneurons secrete fractalkine to promote oligodendrocyte formation in the developing mammalian brain
A Voronova, SA Yuzwa, BS Wang, S Zahr, C Syal, J Wang, DR Kaplan, ...
Neuron 94 (3), 500-516. e9, 2017
Post-translational O-GlcNAcylation is essential for nuclear pore integrity and maintenance of the pore selectivity filter
Y Zhu, TW Liu, Z Madden, SA Yuzwa, K Murray, S Cecioni, N Zachara, ...
Journal of molecular cell biology 8 (1), 2-16, 2016
Proneurogenic ligands defined by modeling developing cortex growth factor communication networks
SA Yuzwa, G Yang, MJ Borrett, G Clarke, GI Cancino, SK Zahr, ...
Neuron 91 (5), 988-1004, 2016
Discovery and characterization of small molecules targeting the DNA-binding ETS domain of ERG in prostate cancer
MS Butler, M Roshan-Moniri, M Hsing, D Lau, A Kim, P Yen, M Mroczek, ...
Oncotarget 8 (26), 42438, 2017
Peripheral nerve single-cell analysis identifies mesenchymal ligands that promote axonal growth
JS Toma, K Karamboulas, MJ Carr, A Kolaj, SA Yuzwa, N Mahmud, ...
Eneuro 7 (3), 2020
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