P450 BM3: the very model of a modern flavocytochrome AW Munro, DG Leys, KJ McLean, KR Marshall, TWB Ost, S Daff, CS Miles, ... Trends in biochemical sciences 27 (5), 250-257, 2002 | 525 | 2002 |
The structure and catalytic mechanism of a poly (ADP-ribose) glycohydrolase D Slade, MS Dunstan, E Barkauskaite, R Weston, P Lafite, N Dixon, ... Nature 477 (7366), 616-620, 2011 | 446 | 2011 |
Atomic description of an enzyme reaction dominated by proton tunneling L Masgrau, A Roujeinikova, LO Johannissen, P Hothi, J Basran, ... Science 312 (5771), 237-241, 2006 | 404 | 2006 |
Overview of organohalide-respiring bacteria and a proposal for a classification system for reductive dehalogenases LA Hug, F Maphosa, D Leys, FE Löffler, H Smidt, EA Edwards, L Adrian Philosophical Transactions of the Royal Society B: Biological Sciences 368 …, 2013 | 329 | 2013 |
Reductive dehalogenase structure suggests a mechanism for B12-dependent dehalogenation KAP Payne, CP Quezada, K Fisher, MS Dunstan, FA Collins, H Sjuts, ... Nature 517 (7535), 513-516, 2015 | 309 | 2015 |
New cofactor supports α, β-unsaturated acid decarboxylation via 1, 3-dipolar cycloaddition KAP Payne, MD White, K Fisher, B Khara, SS Bailey, D Parker, ... Nature 522 (7557), 497-501, 2015 | 238 | 2015 |
UbiX is a flavin prenyltransferase required for bacterial ubiquinone biosynthesis MD White, KAP Payne, K Fisher, SA Marshall, D Parker, NJW Rattray, ... Nature 522 (7557), 502-506, 2015 | 208 | 2015 |
Structure and biochemical properties of the alkene producing cytochrome P450 OleTJE (CYP152L1) from the Jeotgalicoccus sp. 8456 bacterium J Belcher, KJ McLean, S Matthews, LS Woodward, K Fisher, SEJ Rigby, ... Journal of Biological Chemistry 289 (10), 6535-6550, 2014 | 207 | 2014 |
Structure and mechanism of the flavocytochrome c fumarate reductase of Shewanella putrefaciens MR-1 D Leys, AS Tsapin, KH Nealson, TE Meyer, MA Cusanovich, ... nature structural biology 6 (12), 1113-1117, 1999 | 205 | 1999 |
Reengineering orthogonally selective riboswitches N Dixon, JN Duncan, T Geerlings, MS Dunstan, JEG McCarthy, D Leys, ... Proceedings of the National Academy of Sciences 107 (7), 2830-2835, 2010 | 202 | 2010 |
Atomic structure of Mycobacterium tuberculosis CYP121 to 1.06 Å reveals novel features of cytochrome P450 D Leys, CG Mowat, KJ McLean, A Richmond, SK Chapman, ... Journal of Biological Chemistry 278 (7), 5141-5147, 2003 | 196 | 2003 |
Visualization of poly(ADP-ribose) bound to PARG reveals inherent balance between exo- and endo-glycohydrolase activities E Barkauskaite, A Brassington, ES Tan, J Warwicker, MS Dunstan, ... Nature communications 4 (1), 2164, 2013 | 174 | 2013 |
Single-step fermentative production of the cholesterol-lowering drug pravastatin via reprogramming of Penicillium chrysogenum KJ McLean, M Hans, B Meijrink, WB Van Scheppingen, A Vollebregt, ... Proceedings of the National Academy of Sciences 112 (9), 2847-2852, 2015 | 167 | 2015 |
The dimeric form of flavocytochrome P450 BM3 is catalytically functional as a fatty acid hydroxylase R Neeli, HM Girvan, A Lawrence, MJ Warren, D Leys, NS Scrutton, ... FEBS letters 579 (25), 5582-5588, 2005 | 163 | 2005 |
Characterization of active site structure in CYP121: A cytochrome P450 essential for viability of Mycobacterium tuberculosis H37Rv KJ McLean, P Carroll, DG Lewis, AJ Dunford, HE Seward, R Neeli, ... Journal of Biological Chemistry 283 (48), 33406-33416, 2008 | 155 | 2008 |
P450-catalyzed regio-and diastereoselective steroid hydroxylation: efficient directed evolution enabled by mutability landscaping CG Acevedo-Rocha, CG Gamble, R Lonsdale, A Li, N Nett, ... Acs Catalysis 8 (4), 3395-3410, 2018 | 150 | 2018 |
The structure of Mycobacterium tuberculosis CYP125 KJ McLean, P Lafite, C Levy, MR Cheesman, N Mast, IA Pikuleva, D Leys, ... Journal of Biological Chemistry 284 (51), 35524-35533, 2009 | 148 | 2009 |
Crystal structure of the Mycobacterium tuberculosis P450 CYP121-fluconazole complex reveals new azole drug-P450 binding mode HE Seward, A Roujeinikova, KJ McLean, AW Munro, D Leys Journal of Biological Chemistry 281 (51), 39437-39443, 2006 | 147 | 2006 |
Structures of carboxylic acid reductase reveal domain dynamics underlying catalysis D Gahloth, MS Dunstan, D Quaglia, E Klumbys, MP Lockhart-Cairns, ... Nature chemical biology 13 (9), 975-981, 2017 | 145 | 2017 |
Structural basis of kynurenine 3-monooxygenase inhibition M Amaral, C Levy, DJ Heyes, P Lafite, TF Outeiro, F Giorgini, D Leys, ... Nature 496 (7445), 382-385, 2013 | 145 | 2013 |