Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases YNP Chen, MJ LaMarche, HM Chan, P Fekkes, J Garcia-Fortanet, ... Nature 535 (7610), 148-152, 2016 | 776 | 2016 |
Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo WE Dowdle, B Nyfeler, J Nagel, RA Elling, S Liu, E Triantafellow, ... Nature cell biology 16 (11), 1069-1079, 2014 | 648 | 2014 |
H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers M Seiler, A Yoshimi, R Darman, B Chan, G Keaney, M Thomas, ... Nature medicine 24 (4), 497-504, 2018 | 467 | 2018 |
Cancer-associated SF3B1 hotspot mutations induce cryptic 3′ splice site selection through use of a different branch point RB Darman, M Seiler, AA Agrawal, KH Lim, S Peng, D Aird, SL Bailey, ... Cell reports 13 (5), 1033-1045, 2015 | 449 | 2015 |
Protein targeting to the bacterial cytoplasmic membrane P Fekkes, AJM Driessen Microbiology and Molecular Biology Reviews 63 (1), 161-173, 1999 | 371 | 1999 |
The molecular chaperone SecB is released from the carboxy‐terminus of SecA during initiation of precursor protein translocation P Fekkes, C van der Does, AJM Driessen The EMBO journal, 1997 | 276 | 1997 |
Allosteric inhibition of SHP2: identification of a potent, selective, and orally efficacious phosphatase inhibitor J Garcia Fortanet, CHT Chen, YNP Chen, Z Chen, Z Deng, B Firestone, ... Journal of medicinal chemistry 59 (17), 7773-7782, 2016 | 259 | 2016 |
The sec system AJM Driessen, P Fekkes, JPW van der Wolk Current opinion in microbiology 1 (2), 216-222, 1998 | 240 | 1998 |
Gag3p, an outer membrane protein required for fission of mitochondrial tubules P Fekkes, KA Shepard, MP Yaffe The Journal of cell biology 151 (2), 333-340, 2000 | 217 | 2000 |
Preprotein transfer to the Escherichia coli translocase requires the co‐operative binding of SecB and the signal sequence to SecA P Fekkes, JG De Wit, JPW Van Der Wolk, HH Kimsey, CA Kumamoto, ... Molecular microbiology 29 (5), 1179-1190, 1998 | 172 | 1998 |
Structural basis of splicing modulation by antitumor macrolide compounds C Cretu, AA Agrawal, A Cook, CL Will, P Fekkes, PG Smith, R Lührmann, ... Molecular cell 70 (2), 265-273. e8, 2018 | 151 | 2018 |
Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A–SF3b complex T Teng, JHC Tsai, X Puyang, M Seiler, S Peng, S Prajapati, D Aird, ... Nature communications 8 (1), 15522, 2017 | 133 | 2017 |
PrlA4 prevents the rejection of signal sequence defective preproteins by stabilizing the SecA–SecY interaction during the initiation of translocation JPW Van Der Wolk, P Fekkes, A Boorsma, JL Huie, TJ Silhavy, ... The EMBO journal, 1998 | 131 | 1998 |
Identification of TNO155, an allosteric SHP2 inhibitor for the treatment of cancer MJ LaMarche, M Acker, A Argintaru, D Bauer, J Boisclair, H Chan, ... Journal of medicinal chemistry 63 (22), 13578-13594, 2020 | 130 | 2020 |
Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer M Korpal, X Puyang, Z Jeremy Wu, R Seiler, C Furman, HZ Oo, M Seiler, ... Nature communications 8 (1), 103, 2017 | 129 | 2017 |
H3B-6527 is a potent and selective inhibitor of FGFR4 in FGF19-driven hepatocellular carcinoma JJ Joshi, H Coffey, E Corcoran, J Tsai, CL Huang, K Ichikawa, S Prajapati, ... Cancer research 77 (24), 6999-7013, 2017 | 126 | 2017 |
SecA is an intrinsic subunit of the Escherichia coli preprotein translocase and exposes its carboxyl terminus to the periplasm C Van Der Does, T Den Blaauwen, JG De Wit, EH Manting, NA Groot, ... Molecular microbiology 22 (4), 619-629, 1996 | 126 | 1996 |
Zinc stabilizes the SecB binding site of SecA P Fekkes, JG de Wit, A Boorsma, RHE Friesen, AJM Driessen Biochemistry 38 (16), 5111-5116, 1999 | 116 | 1999 |
Domain Interactions of the Peripheral Preprotein Translocase Subunit SecA T den Blaauwen, P Fekkes, JG de Wit, W Kuiper, AJM Driessen Biochemistry 35 (37), 11994-12004, 1996 | 114 | 1996 |
The cryo-EM structure of the SF3b spliceosome complex bound to a splicing modulator reveals a pre-mRNA substrate competitive mechanism of action LI Finci, X Zhang, X Huang, Q Zhou, J Tsai, T Teng, A Agrawal, B Chan, ... Genes & development 32 (3-4), 309-320, 2018 | 110 | 2018 |