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Oleg Gorbatyuk
Oleg Gorbatyuk
Research Associate Professor, University of Alabama at Birmingham
Verified email at uab.edu
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Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to different regions of …
C Burger, OS Gorbatyuk, MJ Velardo, CS Peden, P Williams, S Zolotukhin, ...
Molecular Therapy 10 (2), 302-317, 2004
8982004
The phosphorylation state of Ser-129 in human α-synuclein determines neurodegeneration in a rat model of Parkinson disease
OS Gorbatyuk, S Li, LF Sullivan, W Chen, G Kondrikova, FP Manfredsson, ...
Proceedings of the National Academy of Sciences 105 (2), 763-768, 2008
3692008
Restoration of visual function in P23H rhodopsin transgenic rats by gene delivery of BiP/Grp78
MS Gorbatyuk, T Knox, MM LaVail, OS Gorbatyuk, SM Noorwez, ...
Proceedings of the National Academy of Sciences 107 (13), 5961-5966, 2010
2982010
Adeno-associated virus type 2 VP2 capsid protein is nonessential and can tolerate large peptide insertions at its N terminus
KH Warrington Jr, OS Gorbatyuk, JK Harrison, SR Opie, S Zolotukhin, ...
Journal of virology 78 (12), 6595-6609, 2004
2672004
In vivo RNAi-mediated α-synuclein silencing induces nigrostriatal degeneration
OS Gorbatyuk, S Li, K Nash, M Gorbatyuk, AS Lewin, LF Sullivan, ...
Molecular Therapy 18 (8), 1450-1457, 2010
2332010
Glucose regulated protein 78 diminishes α-synuclein neurotoxicity in a rat model of Parkinson disease
MS Gorbatyuk, A Shabashvili, W Chen, C Meyers, LF Sullivan, M Salganik, ...
Molecular Therapy 20 (7), 1327-1337, 2012
1952012
Effect of 2-mercaptoacetate and 2-deoxy-D-glucose administration on the expression of NPY, AGRP, POMC, MCH and hypocretin/orexin in the rat hypothalamus
V Sergeyev, C Broberger, O Gorbatyuk, T Hökfelt
Neuroreport 11 (1), 117-120, 2000
1392000
Nigrostriatal rAAV-mediated GDNF overexpression induces robust weight loss in a rat model of age-related obesity
FP Manfredsson, N Tumer, B Erdos, T Landa, CS Broxson, LF Sullivan, ...
Molecular Therapy 17 (6), 980-991, 2009
1142009
The molecular chaperone GRP78/BiP as a therapeutic target for neurodegenerative disorders: a mini review
MS Gorbatyuk, OS Gorbatyuk
Journal of genetic syndrome & gene therapy 4 (2), 2013
1072013
ER stress is involved in T17M rhodopsin-induced retinal degeneration
MM Kunte, S Choudhury, JF Manheim, VM Shinde, M Miura, VA Chiodo, ...
Investigative ophthalmology & visual science 53 (7), 3792-3800, 2012
952012
Salivary PYY: a putative bypass to satiety
A Acosta, MD Hurtado, O Gorbatyuk, M La Sala, D Duncan, G Aslanidi, ...
PloS one 6 (10), e26137, 2011
902011
Neurodegeneration: keeping ATF4 on a tight leash
PM Pitale, O Gorbatyuk, M Gorbatyuk
Frontiers in cellular neuroscience 11, 410, 2017
682017
The loss of glucose-regulated protein 78 (GRP78) during normal aging or from siRNA knockdown augments human alpha-synuclein (α-syn) toxicity to rat nigral neurons
M Salganik, VG Sergeyev, V Shinde, CA Meyers, MS Gorbatyuk, JH Lin, ...
Neurobiology of aging 36 (6), 2213-2223, 2015
642015
α-Synuclein expression in rat substantia nigra suppresses phospholipase D2 toxicity and nigral neurodegeneration
OS Gorbatyuk, S Li, FN Nguyen, FP Manfredsson, G Kondrikova, ...
Molecular Therapy 18 (10), 1758-1768, 2010
632010
Localization of agmatine in vasopressin and oxytocin neurons of the rat hypothalamic paraventricular and supraoptic nuclei
OS Gorbatyuk, TA Milner, G Wang, S Regunathan, DJ Reis
Experimental neurology 171 (2), 235-245, 2001
532001
Caspase-7 ablation modulates UPR, reprograms TRAF2-JNK apoptosis and protects T17M rhodopsin mice from severe retinal degeneration
S Choudhury, Y Bhootada, O Gorbatyuk, M Gorbatyuk
Cell death & disease 4 (3), e528-e528, 2013
522013
Retinal degeneration: Focus on the unfolded protein response
M Gorbatyuk, O Gorbatyuk
Molecular vision 19, 1985, 2013
522013
Up-regulation of activating transcription factor 4 induces severe loss of dopamine nigral neurons in a rat model of Parkinson’s disease
JC Gully, VG Sergeyev, Y Bhootada, H Mendez-Gomez, CA Meyers, ...
Neuroscience letters 627, 36-41, 2016
472016
Differential modulation of energy balance by leptin, ciliary neurotrophic factor, and leukemia inhibitory factor gene delivery: microarray deoxyribonucleic acid-chip analysis …
V Prima, M Tennant, OS Gorbatyuk, N Muzyczka, PJ Scarpace, ...
Endocrinology 145 (4), 2035-2045, 2004
462004
Limited ATF4 expression in degenerating retinas with ongoing ER stress promotes photoreceptor survival in a mouse model of autosomal dominant retinitis pigmentosa
Y Bhootada, P Kotla, S Zolotukhin, O Gorbatyuk, Z Bebok, M Athar, ...
PLoS One 11 (5), e0154779, 2016
422016
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