Estrogen receptor-β potency-selective ligands: structure− activity relationship studies of diarylpropionitriles and their acetylene and polar analogues MJ Meyers, J Sun, KE Carlson, GA Marriner, BS Katzenellenbogen, ... Journal of medicinal chemistry 44 (24), 4230-4251, 2001 | 814 | 2001 |
Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism AK Shiau, D Barstad, JT Radek, MJ Meyers, KW Nettles, ... Nature structural biology 9 (5), 359-364, 2002 | 482 | 2002 |
Novel ligands that function as selective estrogens or antiestrogens for estrogen receptor-α or estrogen receptor-β J Sun, MJ Meyers, BE Fink, R Rajendran, JA Katzenellenbogen, ... Endocrinology 140 (2), 800-804, 1999 | 427 | 1999 |
Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2) DR Anderson, MJ Meyers, WF Vernier, MW Mahoney, RG Kurumbail, ... Journal of medicinal chemistry 50 (11), 2647-2654, 2007 | 195 | 2007 |
Estrogen receptor subtype-selective ligands: asymmetric synthesis and biological evaluation of cis-and trans-5, 11-dialkyl-5, 6, 11, 12-tetrahydrochrysenes MJ Meyers, J Sun, KE Carlson, BS Katzenellenbogen, ... Journal of medicinal chemistry 42 (13), 2456-2468, 1999 | 171 | 1999 |
Plasmepsins IX and X are essential and druggable mediators of malaria parasite egress and invasion AS Nasamu, S Glushakova, I Russo, B Vaupel, A Oksman, AS Kim, ... Science 358 (6362), 518-522, 2017 | 167 | 2017 |
Novel tetrahydro-β-carboline-1-carboxylic acids as inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2) JI Trujillo, MJ Meyers, DR Anderson, S Hegde, MW Mahoney, WF Vernier, ... Bioorganic & medicinal chemistry letters 17 (16), 4657-4663, 2007 | 154 | 2007 |
A benzothiophene inhibitor of mitogen-activated protein kinase-activated protein kinase 2 inhibits tumor necrosis factor α production and has oral anti-inflammatory efficacy in … RJ Mourey, BL Burnette, SJ Brustkern, JS Daniels, JL Hirsch, WF Hood, ... Journal of Pharmacology and Experimental Therapeutics 333 (3), 797-807, 2010 | 140 | 2010 |
The hepatitis B virus ribonuclease H is sensitive to inhibitors of the human immunodeficiency virus ribonuclease H and integrase enzymes JE Tavis, X Cheng, Y Hu, M Totten, F Cao, E Michailidis, R Aurora, ... PLoS pathogens 9 (1), e1003125, 2013 | 119 | 2013 |
Discovery of (3S,3aR)-2-(3-Chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-benzo[g]indazole-7-carboxylic Acid (PF-3882845), an Orally Efficacious … MJ Meyers, GB Arhancet, SL Hockerman, X Chen, SA Long, ... Journal of medicinal chemistry 53 (16), 5979-6002, 2010 | 106 | 2010 |
Hydroxylated tropolones inhibit hepatitis B virus replication by blocking viral ribonuclease H activity G Lu, E Lomonosova, X Cheng, EA Moran, MJ Meyers, SFJ Le Grice, ... Antimicrobial agents and chemotherapy 59 (2), 1070-1079, 2015 | 93 | 2015 |
Hepatitis B virus replication is blocked by a 2-hydroxyisoquinoline-1, 3 (2H, 4H)-dione (HID) inhibitor of the viral ribonuclease H activity CW Cai, E Lomonosova, EA Moran, X Cheng, KB Patel, F Bailly, P Cotelle, ... Antiviral research 108, 48-55, 2014 | 79 | 2014 |
Benzothiophene inhibitors of MK2. Part 2: Improvements in kinase selectivity and cell potency DR Anderson, MJ Meyers, RG Kurumbail, N Caspers, GI Poda, SA Long, ... Bioorganic & Medicinal Chemistry Letters 19 (16), 4882-4884, 2009 | 67 | 2009 |
Clinically advanced p38 inhibitors suppress DUX4 expression in cellular and animal models of facioscapulohumeral muscular dystrophy J Oliva, S Galasinski, A Richey, AE Campbell, MJ Meyers, N Modi, ... Journal of Pharmacology and Experimental Therapeutics 370 (2), 219-230, 2019 | 65 | 2019 |
Benzothiophene inhibitors of MK2. Part 1: Structure–activity relationships, assessments of selectivity and cellular potency DR Anderson, MJ Meyers, RG Kurumbail, N Caspers, GI Poda, SA Long, ... Bioorganic & Medicinal Chemistry Letters 19 (16), 4878-4881, 2009 | 58 | 2009 |
Synthesis, antimalarial properties and 2D-QSAR studies of novel triazole-quinine conjugates HM Faidallah, SS Panda, JC Serrano, AS Girgis, KA Khan, KA Alamry, ... Bioorganic & medicinal chemistry 24 (16), 3527-3539, 2016 | 55 | 2016 |
A novel piperazine-based drug lead for cryptosporidiosis from the medicines for malaria venture open-access malaria box RS Jumani, K Bessoff, MS Love, P Miller, EE Stebbins, JE Teixeira, ... Antimicrobial Agents and Chemotherapy 62 (4), 10.1128/aac. 01505-17, 2018 | 53 | 2018 |
Synthesis and antimalarial bioassay of quinine–peptide conjugates SS Panda, MA Ibrahim, H Küçükbay, MJ Meyers, FM Sverdrup, ... Chemical Biology & Drug Design 82 (4), 361-366, 2013 | 44 | 2013 |
Structure-based drug design enables conversion of a DFG-in binding CSF-1R kinase inhibitor to a DFG-out binding mode MJ Meyers, M Pelc, S Kamtekar, J Day, GI Poda, MK Hall, ML Michener, ... Bioorganic & medicinal chemistry letters 20 (5), 1543-1547, 2010 | 44 | 2010 |
Acyclic pyrazole compounds for the inhibition of mitogen activated protein kinase-activated protein kinase-2 C Hanau, S Mershon, M Graneto, M Meyers, S Hegde, I Buchler, K Wu, ... US Patent App. 10/742,494, 2004 | 44 | 2004 |