Aberrant Wnt signaling in leukemia FJT Staal, F Famili, L Garcia Perez, K Pike-Overzet Cancers 8 (9), 78, 2016 | 90 | 2016 |
Activation of the LMO2 oncogene through a somatically acquired neomorphic promoter in T-cell acute lymphoblastic leukemia S Rahman, M Magnussen, TE León, N Farah, Z Li, BJ Abraham, KZ Alapi, ... Blood, The Journal of the American Society of Hematology 129 (24), 3221-3226, 2017 | 78 | 2017 |
Successful preclinical development of gene therapy for recombinase-activating gene-1-deficient SCID L Garcia-Perez, M van Eggermond, L van Roon, SA Vloemans, M Cordes, ... Molecular Therapy Methods & Clinical Development 17, 666-682, 2020 | 45 | 2020 |
Increased vimentin in human α-and β-cells in type 2 diabetes MM Roefs, F Carlotti, K Jones, H Wills, A Hamilton, M Verschoor, ... J Endocrinol 233 (3), 217-27, 2017 | 40 | 2017 |
Functional definition of a transcription factor hierarchy regulating T cell lineage commitment L Garcia-Perez, F Famili, M Cordes, M Brugman, M van Eggermond, ... Science advances 6 (31), eaaw7313, 2020 | 35 | 2020 |
The non-canonical Wnt receptor Ryk regulates hematopoietic stem cell repopulation in part by controlling proliferation and apoptosis F Famili, LG Perez, BAE Naber, JN Noordermeer, LG Fradkin, FJT Staal Cell Death & Disease 7 (11), e2479-e2479, 2016 | 32 | 2016 |
JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia MR Mansour, S He, Z Li, R Lobbardi, BJ Abraham, C Hug, S Rahman, ... Journal of Experimental Medicine 215 (7), 1929-1945, 2018 | 26 | 2018 |
Combining mobilizing agents with busulfan to reduce chemotherapy-based conditioning for hematopoietic stem cell transplantation L Garcia-Perez, L van Roon, MW Schilham, AC Lankester, K Pike-Overzet, ... Cells 10 (5), 1077, 2021 | 12 | 2021 |
Preclinical development of autologous hematopoietic stem cell-based gene therapy for immune deficiencies: a journey from mouse cage to bed side L Garcia-Perez, A Ordas, K Canté-Barrett, P Meij, K Pike-Overzet, ... Pharmaceutics 12 (6), 549, 2020 | 5 | 2020 |
Single-cell immune profiling reveals novel thymus-seeding populations, T cell commitment, and multi-lineage development in the human thymus M Cordes, K Canté-Barrett, EB van den Akker, FA Moretti, SM Kiełbasa, ... bioRxiv, 2022.02. 18.481026, 2022 | 3 | 2022 |
Axin2/Conductin is required for normal haematopoiesis and T Lymphopoiesis JJD de Roo, A Chhatta, L Garcia-Perez, BAE Naber, SA Vloemans, ... Cells 11 (17), 2679, 2022 | 2 | 2022 |
A novel branched DNA-based flowcytometric method for single-cell characterization of gene therapy products and expression of therapeutic genes L Garcia-Perez, MCJA Van Eggermond, E Maietta, MLP Van der Hoorn, ... Frontiers in Immunology 11, 607991, 2021 | 2 | 2021 |
ImSpectR: R package to quantify immune repertoire diversity in spectratype and repertoire sequencing data M Cordes, K Pike-Overzet, M van Eggermond, S Vloemans, MR Baert, ... Bioinformatics 36 (6), 1930-1932, 2020 | 2 | 2020 |
Optimised rag1 deficient gene therapy FJT Staal, PO Karin, L Garcia-perez, MCJA Van Eggermond, ... US Patent App. 17/438,135, 2022 | | 2022 |
From stem cells to functional l mphoc tes: cell differentiation and gene therap implementation for RAG-SCID L García Pérez Leiden University, 2021 | | 2021 |
A new gene therapy method to assess transduction efficiency at the single-cell level L Garcia-Perez, M van Eggermond, E Maietta, K Pike-Overzet, FJT Staal HUMAN GENE THERAPY 30 (11), A30-A30, 2019 | | 2019 |
Developing stem cell-based gene therapy for RAG1 deficient-SCID FJT Staal, L Garcia-Perez, M van Eggermont, L van Roon, S Vloemans, ... HUMAN GENE THERAPY 29 (12), A24-A24, 2018 | | 2018 |
Reducing stem cell conditioning for SCID gene therapy LG Perez, L Roon, MW Schilham, AC Lankester, K Pike-Overzet, ... Human Gene Therapy 28 (12), A88-A88, 2017 | | 2017 |