An open-label, two-arm, phase I trial of recombinant human interleukin-21 in patients with metastatic melanoma ID Davis, BK Skrumsager, J Cebon, T Nicholaou, JW Barlow, NPH Moller, ... Clinical Cancer Research 13 (12), 3630-3636, 2007 | 188 | 2007 |
Interleukin‐21 activates human natural killer cells and modulates their surface receptor expression K Skak, KS Frederiksen, D Lundsgaard Immunology 123 (4), 575-583, 2008 | 168 | 2008 |
Clinical and biological efficacy of recombinant human interleukin-21 in patients with stage IV malignant melanoma without prior treatment: a phase IIa trial ID Davis, B Brady, RF Kefford, M Millward, J Cebon, BK Skrumsager, ... Clinical Cancer Research 15 (6), 2123-2129, 2009 | 160 | 2009 |
IL-21 induces in vivo immune activation of NK cells and CD8+ T cells in patients with metastatic melanoma and renal cell carcinoma KS Frederiksen, D Lundsgaard, JA Freeman, SD Hughes, TL Holm, ... Cancer Immunology, Immunotherapy 57, 1439-1449, 2008 | 138 | 2008 |
Interleukin 21: combination strategies for cancer therapy K Skak, M Kragh, D Hausman, MJ Smyth, PV Sivakumar Nature reviews Drug discovery 7 (3), 231-240, 2008 | 133 | 2008 |
Interleukin-21 signaling: functions in cancer and autoimmunity ID Davis, K Skak, MJ Smyth, PEG Kristjansen, DM Miller, PV Sivakumar Clinical cancer research 13 (23), 6926-6932, 2007 | 115 | 2007 |
Histone deacetylase inhibitors: a new class of immunosuppressors targeting a novel signal pathway essential for CD154 expression S Skov, K Rieneck, LF Bovin, K Skak, S Tomra, BK Michelsen, N Ødum Blood, The Journal of the American Society of Hematology 101 (4), 1430-1438, 2003 | 107 | 2003 |
IL‐21: roles in immunopathology and cancer therapy H Søndergaard, K Skak Tissue antigens 74 (6), 467-479, 2009 | 90 | 2009 |
Interleukin 21 therapy increases the density of tumor infiltrating CD8+ T cells and inhibits the growth of syngeneic tumors H Søndergaard, KS Frederiksen, P Thygesen, ED Galsgaard, K Skak, ... Cancer Immunology, Immunotherapy 56, 1417-1428, 2007 | 87 | 2007 |
Distinct molecular signatures of mild extrinsic and intrinsic atopic dermatitis BC Martel, T Litman, A Hald, H Norsgaard, P Lovato, B Dyring‐Andersen, ... Experimental dermatology 25 (6), 453-459, 2016 | 77 | 2016 |
Improved β-Cell Survival and Reduced Insulitis in a Type 1 Diabetic Rat Model After Treatment With a β-Cell–Selective KATP Channel Opener K Skak, CF Gotfredsen, D Lundsgaard, JB Hansen, J Sturis, H Markholst Diabetes 53 (4), 1089-1095, 2004 | 53 | 2004 |
IL-21 induces apoptosis of antigen-specific CD8+ T lymphocytes BR Barker, JG Parvani, D Meyer, AS Hey, K Skak, NL Letvin The Journal of Immunology 179 (6), 3596-3603, 2007 | 44 | 2007 |
Ingenol mebutate signals via PKC/MEK/ERK in keratinocytes and induces interleukin decoy receptors IL1R2 and IL13RA2 SN Freiberger, PF Cheng, G Iotzova-Weiss, J Neu, Q Liu, P Dziunycz, ... Molecular cancer therapeutics 14 (9), 2132-2142, 2015 | 43 | 2015 |
Intratumoral interleukin-21 increases antitumor immunity, tumor-infiltrating CD8+ T-cell density and activity, and enlarges draining lymph nodes H Søndergaard, ED Galsgaard, M Bartholomaeussen, PT Straten, ... Journal of Immunotherapy 33 (3), 236-249, 2010 | 40 | 2010 |
The combination of IL-21 and IFN-α boosts STAT3 activation, cytotoxicity and experimental tumor therapy KW Eriksen, H Søndergaard, A Woetmann, T Krejsgaard, K Skak, ... Molecular immunology 46 (5), 812-820, 2009 | 31 | 2009 |
The TATA-less rat GAD65 promoter can be activated by Sp1 through non-consensus elements K Skak, BK Michelsen Gene 236 (2), 231-241, 1999 | 30 | 1999 |
IL‐21 Modulates Activation of NKT Cells in Patients with Stage IV Malignant Melanoma JM Coquet, K Skak, ID Davis, MJ Smyth, DI Godfrey Clinical & translational immunology 2 (10), e6, 2013 | 27 | 2013 |
Endogenous IL-21 restricts CD8+ T cell expansion and is not required for tumor immunity H Søndergaard, JM Coquet, AP Uldrich, N McLaughlin, DI Godfrey, ... The Journal of Immunology 183 (11), 7326-7336, 2009 | 24 | 2009 |
Immune activation in advanced cancer patients treated with recombinant IL-21: multianalyte profiling of serum proteins MG Dodds, KS Frederiksen, K Skak, LT Hansen, D Lundsgaard, ... Cancer immunology, immunotherapy 58, 843-854, 2009 | 23 | 2009 |
Local activation of dendritic cells leads to insulitis and development of insulin-dependent diabetes in transgenic mice expressing CD154 on the pancreatic β-cells C Haase, K Skak, BK Michelsen, H Markholst Diabetes 53 (10), 2588-2595, 2004 | 22 | 2004 |